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A 6-gene signature identifies four molecular subgroups of neuroblastoma

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Title: A 6-gene signature identifies four molecular subgroups of neuroblastoma
Authors: Abel, Frida
Dalevi, Daniel
Nethander, Maria
Jörnsten, Rebecka
De Preter, Katleen
Vermuelen, Joëlle
Stallings, Raymond
Kogner, Per
Maris, John
Nilsson, Staffan
Issue Date: 14-Apr-2011
Publication type: article, peer reviewed scientific
Organization: Department of Clinical Genetics, Gothenburg University, Gothenburg, Sweden; Genomics Core Facility, Gothenburg University, Gothenburg, Sweden
Citation: Cancer Cell International. 2011 Apr 14;11(1):9
Abstract: Abstract Background There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene MYCN (MNA) and low expression of the favourable marker NTRK1. Recently, mutations or high expression of the familial predisposition gene Anaplastic Lymphoma Kinase (ALK) was associated to unfavourable biology of sporadic NB. Also, various other genes have been linked t... more
Description: © 2011 Abel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Articles / Artiklar Institutionen för kliniska vetenskaper



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