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Identification of gliadin-binding peptides by phage display


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Title: Identification of gliadin-binding peptides by phage display
Authors: Chen, Tingsu
Hoffmann, Karolina
Östman, Sofia
Sandberg, Ann-Sofie
Olsson, Olof
Issue Date: 17-Feb-2011
Publication type: article, peer reviewed scientific
Organization: Department of Plant and Environmental Sciences, University of Gothenburg; Department of Cell and Molecular Biology, University of Gothenburg; Department of Clinical Bacteriology, University of Gothenburg
Citation: BMC Biotechnology. 2011 Feb 17;11(1):16
Abstract: Abstract Background Coeliac disease (CD) is a common and complex disorder of the small intestine caused by intolerance to wheat gluten and related edible cereals like barley and rye. Peptides originating from incomplete gliadin digestion activate the lamina propria infiltrating T cells to release proinflammatory cytokines, which in turn cause profound tissue remodelling of the small intestinal wall. There is no cure for CD except refraining from consuming gluten-containing products. Results Phag... more
ISBN: http://dx.doi.org/10.1186/1472-6750-11-16
Description: © 2011 Chen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/24963
Appears in Collections:Articles / Department of Plant and Environmental Sciences

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