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Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S - Scandinavian Starch for Severe Sepsis/Septic Shock trial): Study protocol, design and rationale for a double-blinded, randomised clinical trial


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Title: Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S - Scandinavian Starch for Severe Sepsis/Septic Shock trial): Study protocol, design and rationale for a double-blinded, randomised clinical trial
Authors: Perner, Anders
Haase, Nicolai
Wetterslev, Jorn
Åneman, Anders
Tenhunen, Jyrki
Guttormsen, Anne Berit
Klemenzson, Gudmundur
Pott, Frank
Bodker, Karen Doris
Bådstolokken, Per Martin
Bendtsen, Asger
Soe-Jensen, Peter
Tousi, Hamid
Bestle, Morten
Pawlowicz, Malgorzata
Winding, Robert
Bülow, Hans-Henrik
Kancir, Claude
Steensen, Morten
Nielsen, Jonas
Fogh, Bjarne
Madsen, Kristian R
Larsen, Nils H
Carlsson, Marcela
Wiis, Jorgen
Petersen, John Asger
Iversen, Susanne
Schoidt, Ole
Leivdal, Siv
Berezowicz, Pawel
Pettilä, Ville
Ruokonen, Esko
Klepstad, Pål
Karlsson, Sari
Kaukonen, Maija
Rutanen, Juha
Karason, Sigurbergur
Kjaeldgaard, Anne Lene
Holst, Lars Brokso
Wernerman, Jan
Critical Care Trials Group, Scandinavian
Issue Date: 27-Jan-2011
Publication type: article, peer reviewed scientific
Organization: Department of Intensive Care, Sahlgrenska University Hospital, Göteborg
Citation: Trials. 2011 Jan 27;12(1):24
Abstract: Abstract Background By tradition colloid solutions have been used to obtain fast circulatory stabilisation in shock, but high molecular weight hydroxyethyl starch (HES) may cause acute kidney failure in patients with severe sepsis. Now lower molecular weight HES 130/0.4 is the preferred colloid in Scandinavian intensive care units (ICUs) and 1st choice fluid for patients with severe sepsis. However, HES 130/0.4 is largely unstudied in patients with severe sepsis. Methods/Design The 6S trial will... more
ISBN: http://dx.doi.org/10.1186/1745-6215-12-24
Description: © 2011 Perner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/24875
Appears in Collections:Articles / Artiklar Institutionen för kliniska vetenskaper

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