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Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide


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Title: Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide
Authors: Park, Eun-Hee
Zhang, Fan
Warringer, Jonas
Sunnerhagen, Per
Hinnebusch, Alan G
Issue Date: 26-Jan-2011
Publication type: article, peer reviewed scientific
Organization: Department of Cell and Molecular Biology, Lundberg Laboratory, University of Gothenburg
Citation: BMC Genomics. 2011 Jan 26;12(1):68
Abstract: Abstract Background Eukaryotic translation initiation factor 4G (eIF4G) is thought to influence the translational efficiencies of cellular mRNAs by its roles in forming an eIF4F-mRNA-PABP mRNP that is competent for attachment of the 43S preinitiation complex, and in scanning through structured 5' UTR sequences. We have tested this hypothesis by determining the effects of genetically depleting eIF4G from yeast cells on global translational efficiencies (TEs), using gene expression microarrays to ... more
ISBN: http://dx.doi.org/10.1186/1471-2164-12-68
Description: © 2011 Park et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/24871
Appears in Collections:Artiklar / Articles Department of Cell and Molecular Biology / Institutionen för cell- och molekylärbiologi

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