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Energy-metabolic aspects of ischemia and pre-treatment: studies in porcine myocardium


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Title: Energy-metabolic aspects of ischemia and pre-treatment: studies in porcine myocardium
Authors: Ahlström, Katarina
E-mail: katarina.ahlstrom@vgregion.se
Issue Date: 23-Aug-2011
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Anesthesiology & Intensive Care Medicine
Parts of work: I Metabolic responses in ischemic myocardium after inhalation of carbon monoxide. Ahlström K, Biber B, Aberg A, Waldenström A, Ronquist G, Abrahamsson P, Strandén P, Johansson G, Haney MF. Acta Anaesthesiol Scand. 2009 Sep;53(8):1036-42. Epub 2009 May 6.
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II Ischaemic pre-conditioning means an increased adenosine metabolism with decreased glycolytic flow in ischaemic pig myocardium. Aberg AM, Ahlström K, Abrahamsson P, Waldenström A, Ronquist G, Hauck P, Johansson G, Biber B, Haney M. Acta Anaesthesiol Scand. 2010 Nov;54(10):1257-64. doi: 10.1111/j.1399-6576.2010.02312.x.
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III Exogenous carbon monoxide does not affect cell membrane energy availability assessed by sarcolemmal calcium fluxes during myocardial ischaemia-reperfusion in the pig. Ahlström K, Biber B, Åberg AM, Abrahamsson P, Johansson G, Ronquist G, Waldenström A, Haney MF. Eur J Anaesthesiol. 2011 May;28(5):356-62.
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IV Adenosine utilization as a substrate for glycolysis during myocardial ischemia after ischemic preconditioning is dependent on intact purine nucleoside phosphorylase activity. Ahlström K, Biber B, Aberg AM, Waldenström A, Ronquist G, Abrahamsson P, Johansson G, Seeman-Lodding H, Haney MF
Date of Defence: 2011-09-09
Disputation: Fredagen den 9 september, kl 13.00, Thorax Konferensrum, Sahlgrenska Universitetssjukhuset, Sahlgrenska, Blå Stråket 5, (våning 5), Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: myocardial ischemia
adenosine
preconditioning
carbon monoxide
Abstract: The focus of this thesis is to clarify mechanisms involved in protective pre-treatment of ischemia by carbon monoxide (CO) and ischemic preconditioning (IP), so that new pro-tective therapies can be designed. This is studied in heart muscle, where the clinical gain would ultimately be to be able to prolong the period during a threatened myocardial infarction where permanent injury can be prevented. The aim is to elucidate energy meta-bolic relations as a basis for temporary metabolic adaptation ... more
ISBN: 978-91-628-8284-6
URI: http://hdl.handle.net/2077/24621
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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