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Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/24136

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Title: Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers
Authors: Walker, Logan C
Fredericksen, Zachary S
Wang, Xianshu
Tarrell, Robert
Pankratz, Vernon S
Lindor, Noralane M
Beesley, Jonathan
Healey, Sue
Chen, Xiaoqing
kConFab, The
Stoppa-Lyonnet, Dominique
Tirapo, Carole
Giraud, Sophie
Mazoyer, Sylvie
Muller, Daniele
Fricker, Jean-Pierre
Delnatte, Capucine
GEMO Study Collaborators, The
Schmutzler, Rita K
Wappenschmidt, Barbara
Engel, Christoph
Schonbuchner, Ines
Deissler, Helmut
Meindl, Alfons
Hogervorst, Frans B
Verheus, Martijn
Hooning, Maartje J
van den Ouweland, Ans MW
Nelen, Marcel R
Ausems, Margreet GEM
Aalfs, Cora M
van Asperen, Christi J
Devilee, Peter
Gerrits, Monique M
Waisfisz, Quinten
Hebon, The
Szabo, Csilla I
ModSQuaD, The
Easton, Douglas F
Peock, Susan
Cook, Margaret
Oliver, Clare T
Frost, Debra
Harrington, Patricia
Evans, D GARETH
Lalloo, Fiona
Eeles, Ros
Izatt, Louise
Chu, Carol
Davidson, Rosemarie
Eccles, Diana
Ong, Kai-Ren
Cook, Jackie
Embrace, The
Rebbeck, Tim
Nathanson, Katherine L
Domchek, Susan M
Singer, Christian F
Gschwantler-Kaulich, Daphne
Dressler, Anne-Catharina
Pfeiler, Georg
Godwin, Andrew K
Heikkinen, Tuomas
Nevanlinna, Heli
Agnarsson, Bjarni A
Caligo, Maria Adelaide
Olsson, Hakan
Kristoffersson, Ulf
Liljegren, Annelie
Arver, Brita
Karlsson, Per
Melin, Beatrice
Swe-brca, The
Sinilnikova, Olga M
McGuffog, Lesley
Antoniou, Antonis C
Chenevix-Trench, Georgia
Spurdle, Amanda B
Couch, Fergus J
Issue Date: 29-Nov-2010
Publication type: article, peer reviewed scientific
Organization: Department of Oncology, Sahlgrenska University Hospital, Göteborg
Citation: Breast Cancer Research. 2010 Nov 29;12(6):R102
Abstract: Abstract Introduction Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies. Methods We successfully genotyped 24 SNPs in a coh... more
ISBN: http://dx.doi.org/10.1186/bcr2785
Description: © 2010 Walker et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/24136
Appears in Collections:Articles / Artiklar Institutionen för kliniska vetenskaper

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