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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis


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Title: Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis
Authors: Jochems, Caroline
Islander, Ulrika
Erlandsson, Malin
Engdahl, Cecilia
Lagerquist, Marie
Gjertsson, Inger
Ohlsson, Claes
Holmdahl, Rikard
Carlsten, Hans
Issue Date: 16-Dec-2010
Publication type: article, peer reviewed scientific
Organization: Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Göteborg University, Göteborg
Citation: BMC Musculoskeletal Disorders. 2010 Dec 16;11(1):284
Abstract: Abstract Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-ncf1*/*mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-ncf1*/*mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endoge... more
ISBN: http://dx.doi.org/10.1186/1471-2474-11-284
Description: © 2010 Jochems et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/24135
Appears in Collections:Articles / Department of Rheumatology and Inflammation Research

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