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Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and lymph nodes


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Title: Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and lymph nodes
Authors: Samuelsson, Kristin
E-mail: krisam@chem.gu.se
Issue Date: 5-Nov-2010
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: I. Accumulation of FITC near stratum corneum –visualizing epidermal distribution of a strong sensitizer using two-photon microscopy. Contact Dermatitis 2009: 61: 91–100.
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II. The distribution of a fluorescent allergen in skin and draining lymph nodes. Unpublished manuscript

III. Diphenylthiourea, a common rubber chemical, is bioactivated to potent skin sensitizers. Accepted manuscript. Chemical Research in Toxicology
Date of Defence: 2010-11-26
Disputation: Fredagen den 26 november 2010, kl 13.15, KB, Kemigården 4, Göteborgs Universitet och Chalmers Tekniska Högskola
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Allergic contact dermatitis
Covalent binding
Biotransformation
Diphenylthiourea
Cytochrome P450
Gel electrophoresis
Isothiocyanate
Laser scanning confocal microscopy
Local lymph node assay
Metabolism
Mouse ear swelling test
Penetration
Prohapten
Sensitization
Skin
Two-photon microscopy
Abstract: Development of contact dermatitis can be caused by electrophilic compounds (haptens) or prohaptens that come into contact with the skin. A prohapten is a compound seemingly harmless at first sight that can be transformed into reactive metabolites by metabolizing enzymes in the skin to become a hapten. The perquisites for a compound to induce contact allergy are, absorption into the skin, bioactivation of prohaptens, and reaction with endogenous proteins. The hapten-protein complex will be furthe... more
ISBN: 978-91-628-8201-3
URI: http://hdl.handle.net/2077/23775
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kemi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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