Faculty of Science / Naturvetenskapliga fakulteten >
Department of Chemistry / Institutionen för kemi (-2011) >
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi >

Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites Synthesis, Characterization and Avoidance

Please use this identifier to cite or link to this item:

Files in This Item:

File Description SizeFormat
gupea_2077_22031_1.pdfThesis frame997KbAdobe PDF
gupea_2077_22031_2.pdfAbstract78KbAdobe PDF
Title: Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites Synthesis, Characterization and Avoidance
Authors: Johansson Mali'n, Tove
Issue Date: 3-May-2010
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: I Johansson, T., Weidolf, L., Jurva, U. (2007). Mimicry of Phase I Drug Metabolism - Novel Methods for Metabolite Characterization and Synthesis. Rapid Communications in Mass Spectrometry 21, 2323-2331

II Johansson, T., Jurva, U., Grönberg, G., Weidolf, L., Masimirembwa, C. (2009). Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry and NMR. Drug Metabolism and Disposition 37, 571-579.

III Johansson Mali'n, T., Weidolf, L., Castagnoli, N., Jr., Jurva, U. (2010). P450-Catalyzed vs. Electrochemical Oxidation of Haloperidol Studied by Ultra-Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry. Accepted for publication in Rapid Communications in Mass Spectrometry.

IV Johansson, T., Weidolf, L., Popp, F., Tacke, R., Jurva, U. (2010) In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange. Drug Metabolism and Disposition 38, 73-83.

Date of Defence: 2010-05-12
Disputation: 9.15 i sal KB, Kemigården 4, Göteborgs universitet och Chalmers Tekniska Högskola.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Cytochrome P450
Electrochemical oxidation
Metabolic activation
Reactive metabolite
Abstract: ABSTRACT During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and intermediates. Reactive metabolites may represent obstacles in the development and use of drugs, due to their potential toxicity. The formation of reactive metabolites often involves oxidation reactions and the cytochrome P450 (CYP) enzymes are the most important enzymes catalyzin... more
ISBN: 978-91-628-8089-7
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kemi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



© Göteborgs universitet 2011