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dc.contributor.authorDonati, Mauro
dc.date.accessioned2009-05-18T06:52:55Z
dc.date.available2009-05-18T06:52:55Z
dc.date.issued2009-05-18T06:52:55Z
dc.identifier.isbn978-91-628-7736-1
dc.identifier.urihttp://hdl.handle.net/2077/20298
dc.description.abstractInflammatory and immune reactions to microbial plaque are the predominant features of periodontitis. Epidemiological studies revealed that differences in periodontitis among individuals could not be explained by differences in oral hygiene alone and that not everybody is equally susceptible. Periodontitis is considered to be a multifactorial disease where the interaction of multiple genetic and environmental components results into disease expression. The objectives of the present series of studies were (i) to investigate the association of gene polymorphisms related to some immune regulation components (IL10, TNFA, IL4RA CD14) with severe chronic periodontitis (studies I-II), (ii) to study the local expression of some immune regulation components in relation to gene polymorphisms in subjects with chronic periodontitis (study III), (iii) to study the correlation between inflammatory cells and functional markers in gingival lesions obtained from subjects with severe chronic periodontitis (study IV) (iv) and to study the reaction of B-1a cells to de novo plaque formation in subjects who were treated for severe chronic periodontitis (study V). It was demonstrated that the proportion of subjects that exhibited the –1087 IL10 GG genotype was significantly larger in the group with severe periodontitis than in the group of healthy controls (study I), that the proportion of subjects that exhibited the –159 CD14 TT genotype was significantly smaller in the group of subjects with severe periodontitis than in the periodontally healthy group (study II) and that the proportion of IL-10 positive cells in the peripheral area of periodontitis lesions was significantly larger in subjects with the – 1087 IL10 GG genotype than in subjects with AG or AA genotypes (study III). It was also observed that B cells (B-1a cells and B-2 cells) occurred in larger proportions than T cells, plasma cells and neutrophils in periodontitis lesions and a significant correlation was found between percentages of B-1a cells and plasma cells and between densities of B-lymphocytes and plasma cells (study IV). Further, biopsies retrieved after 3 weeks of plaque accumulation contained larger proportions of B-1a cells than biopsies representing healthy sites (study V).en
dc.language.isoengen
dc.relation.haspartI. Berglundh T, Donati M, Hahn-Zoric M, Hanson LA, Padyukov L. (2003) Association of the -1087 IL-10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians. Journal of Clinical Periodontology 30: 249-254.::PMID::12631183en
dc.relation.haspartII. Donati M, Berglundh T, Hytönen AM, Hahn-Zoric M, Hanson LA, Padyukov L. (2005) Association of the -159 CD14 polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians. Journal of Clinical Periodontology 32: 474-479::PMID::15842262en
dc.relation.haspartIII. Donati M, Liljenberg B, Padyukov L, Berglundh T. (2008) Local expression of interleukin-10 and mCD14 in relation to the -1087 IL- 10 and -159 CD14 gene polymorphisms in chronic periodontitis. Journal of Periodontology 79: 517-524::PMID::18315435en
dc.relation.haspartIV. Donati M, Liljenberg B, Zitzmann NU, Berglundh T. (2009) B-1a cells and plasma cells in periodontitis lesions. Journal of Periodontal Research (Accepted for publication)en
dc.relation.haspartV. Donati M, Liljenberg B, Zitzmann NU, Berglundh T. (2009) B-1a cells in experimental gingivitis in man. Journal of Periodontology (Accepted for publication)en
dc.subjectAlleleen
dc.subjectB-lymphocyteen
dc.subjectcell-surface moleculeen
dc.subjectcytokineen
dc.subjectgene expressionen
dc.subjectgenotypeen
dc.subjectgingivitisen
dc.subjecthost responseen
dc.subjectinflammation, periodontal diseaseen
dc.titleGene Polymorphisms and Related Cell Markers in Periodontitis Lesionsen
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailmauro.donati@odontologi.gu.seen
dc.type.degreeDoctor of Philosophy (Odontology)en
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academyen
dc.gup.departmentInstitute of Odontology. Department of Periodontologyen
dc.gup.defenceplaceMåndagen den 8 juni 2009 kl. 9.00. Föreläsningssal 3, Odontologen, Medicinaregatan 12 E, Göteborgen
dc.gup.defencedate2009-06-08
dc.gup.dissdb-fakultetSA


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