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Tissue remodelling proteases as prognostic factors in colon and rectal cancer


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/19379

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Title: Tissue remodelling proteases as prognostic factors in colon and rectal cancer
Authors: Langenskiöld, Marcus
E-mail: marcus.langenskiold@vgregion.se
Issue Date: 8-May-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Marcus Langenskiöld, Lena Holmdahl, Peter Falk, Marie-Louise Ivarsson. Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer. Int J Colorectal Dis. 2005 May;20(3):245-52.
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II. Marcus Langenskiöld, Lena Holmdahl, Peter Falk, Eva Angenete, Marie-Louise Ivarsson. Increased TGF-beta1 protein expression in patients with advanced colorectal cancer. J Surg Oncol. 2008 Apr 1;97(5):409-15.
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III. Marcus Langenskiöld, Lena Holmdahl, Eva Angenete, Peter Falk, Svante Nordgren, Marie-Louise Ivarsson. Differential prognostic impact of uPA and PAI-1 in colon and rectal cancer. Submitted.

IV. Marcus Langenskiöld, Lena Holmdahl, Eva Angenete, Peter Falk, Christina Kåbjörn-Gustafsson, Marie-Louise Ivarsson. Intestinal mucosal MMP-1 is a prognostic factor in colon cancer. In manuscript.
Date of Defence: 2009-05-28
Disputation: Torsdagen den 28 maj 2009, kl. 13.00, Stora Aulan, Centralkliniken, Sahlgrenska Universitetssjukhuset/Östra, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: extracelluar matrix
survival
staging
colorectal cancer
mucosa
stroma
Abstract: Background: Colorectal cancer is the third most common cancer in Sweden and the main treatment is surgery. The TNM classification is the principal staging tool, although insufficient in identifying all patients with poor survival. The identification of molecular prognostic markers would be important in order to further aid in the identification of these patients. Components participating in the remodellation of extracellular matrix were analysed for their association with tumour progression and ... more
ISBN: 978-91-628-7769-9
URI: http://hdl.handle.net/2077/19379
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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