Sahlgrenska Academy / Sahlgrenska akademin
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Early detection of critical congenital heart defects in Sweden - with a focus on coarctation of the aorta
(2023-05-30)Introduction: Despite the implementation of prenatal and neonatal screening, newborn infants with critical congenital heart defects (CCHD) remain at risk of being discharged undiagnosed, particularly newborns with coarcation ... -
Oropharyngeal dysphagia in adults: Prevalence, professional practices, patient perspectives and treatment outcomes
(2023-05-25)Background: Oropharyngeal dysphagia (OD) is defined as any disruption in the transportation of food/liquids safely and efficiently from the mouth, through the pharynx and into the esophagus. The underlying causes of OD ... -
Distal femur fracture in the elderly patient
(2023-05-25)Studies on the epidemiology of distal femur fractures show a vast increase in low-energy trauma-associated fractures in older ages. Age-related changes in bones lead to loss of bone matrix and increased porosity, which ... -
Genomic signatures in viruses
(2023-05-25)In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, ... -
Rho-GTPases in Rheumatoid Arthritis
(2023-05-24)The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase ... -
Treatment of Head and Neck Cancer, Effects on Health-Related Quality of Life and Nutrition
(2023-05-24)The aim of this thesis was to explore the impact of treatment on health-related quality of life (HRQoL), fatigue and nutrition in head and neck cancer (HNC) patients. The tumour locations often induce problems with swallowing ... -
Necrotizing enterocolitis - growth, bone health and intestinal microbiota during childhood
(2023-05-24)Necrotizing enterocolitis (NEC) is a dreaded gastrointestinal disease primarily affecting infants born preterm. Despite extensive research, NEC is still one of the most devastating diseases in neonatal intensive care. ... -
On the diagnosis and treatment of intraepidermal carcinoma
(2023-05-24)Abstract: Intraepidermal carcinoma (IEC), also known as Bowen disease (BD) or squamous cell carcinoma (SCC) in situ, is a precursor to SCC. The incidence of IEC is increasing rapidly in fair-skinned populations with a ... -
Machine learning and big data for personalized epilepsy treatment
(2023-05-23)Finding an effective anti-seizure medication (ASM) with minimal side effects is a challenge. Patient characteristics are used to guide treatment selection, but about half of the patients with epilepsy do not achieve seizure ... -
Dietary intake, nutritional status and energy metabolism in individuals with anorexia nervosa - Effects of specialized eating disorder hospital treatment
(2023-05-23)Objective: Anorexia nervosa (AN) is a life-threatening condition affecting around 1% of the population. The aim of this thesis was to study nutritional aspects before and after specialized eating disorder hospital ... -
The proteasome as a target for cancer therapy
(2023-05-23)The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The ... -
Small-scale dosimetry methods for normal tissues after radioembolization and peptide receptor radiotherapies; a focus on the liver parenchyma and the bane marrow
(2023-05-23)Radionuclide therapies are increasingly used in cancer treatments as they have been proven to be both effective and safe. As biodistributions and uptake vary widely between patients, a standardized approach is bound to ... -
Multimodal and multiscale characterization of bone and bone interfaces in health and disease
(2023-05-16)Seeing is believing. Our understanding of phenomena often involves their direct observation. However, bone architecture is challenging to visualize given its multi-level hierarchical organization. In this thesis, bone and ... -
lnclusion body myositis - Genetic, clinical, and epidemiological aspects
(2023-05-16)The inflammatory myopathy inclusion body myositis (IBM) is characterized by progressive muscle weakness and dysphagia in individuals over 45 years of age. Muscle biopsy shows inflammatory infiltrates, vacuoles with protein ... -
Characterization of Epstein-Barr virus non-coding RNAs in infected cells
(2023-05-16)Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial ... -
On massive weight loss and body contour
(2023-05-16)Abstract Background/Aims: Bariatric surgery is an effective treatment for severe obesity. However, massive weight loss is associated with adverse effects, such as excess skin. The overall aim of this thesis was to investigate ... -
Att mötas utan att ses - om partnerskap och personcentrerad vård på distans
(2023-05-16)The aim of this thesis was to evaluate and describe person-centred care over the telephone to people with chronic obstructive pulmonary disease (COPD) or chronic heart failure (CHF) and to elucidate informal carers’ ... -
Vitamin D during pregnancy in relation to childhood growth, overweight and obesity
(2023-05-15)The aim of this thesis is to investigate the association between maternal vitamin D intake and status in pregnancy and the child´s growth and risk of overweight and obesity in childhood. Data from the Norwegian Mother, ... -
Cardiometabolic risk indicators in bipolar disorders
(2023-05-15)In addition to disabling mood episodes, bipolar disorders (BDs) predispose individuals to high cardiovascular disease (CVD) risk. This thesis explores the association between BDs and the metabolic risk indicators body mass ... -
Andning och träning i medveten närvaro för personer med hjärtsvikt - studier av erfarenheter och effekter på symtom och tecken, välbefinnande och hälsa
(2023-05-15)Despite care and treatment, many patients with heart failure (HF) are limited by symptoms, such as shortness of breath (SOB) and fatigue, that is difficult to treat. Research shows that slow breathing and mindfulness-based ...
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