• Exploring small airways using breath analyses 

  Viklund, Emilia

  Background: Airway irritants such as allergens, tobacco smoke and viruses may cause damage in the small airways, usually undetected with routine diagnostic methods. Analyses of endogenously produced nitric oxide (NO) and ...

• Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin 

  Hansson, Erik

  This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ...

• Nutritional impact on health in patients with Rheumatoid Arthritis 

  Hulander, Erik

  Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ...

• Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer 

  Keane, Simon

  Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ...

• lntestinal microenvironment, epithelial barrier interactions and human milk oligosaccharide supplementation in irritable bowel syndrome 

  Iribarren Gómez, Cristina

  Alterations of the microbiota-host interactions at the mucosal border may be of importance in symptom generation in irritable bowel syndrome (IBS), a disorder of gut-brain interaction. Hence, microbiota-targeted interventions ...

• To give birth in late- and post-term pregnancy - women's experiences and perspectives 

  Nilvér, Helena

  Childbirth is a lifechanging event, and women carry with them the experience throughout life. Around one in five pregnancies reach gestational week 41. When to recommend induction of labour for those extending 41 gestational ...

• Proximal and distal humeral fractures. Outcome of primary arthroplasty 

  Jonsson, Eythor Örn

  This thesis deals with both proximal humeral fractures and elbow injuries, especially distal humeral fractures. The main focus is difficult fractures in the elderly. Few randomized controlled trials (RCTs) are available. ...

• Allergic and non-allergic asthma: Translational research in immunology 

  Boberg, Emma

  Asthma is a chronic heterogeneous respiratory disease affecting more than 300 million people globally. The different phenotypes, including allergic and nonallergic asthma, are driven by different underlying mechanisms ...

• Supporting mental health - Effects, communicative processes and experiences of a person-centred eHealth intervention 

  Cederberg, Matilda

  Corresponding to the appeal to develop supportive strategies for people on sick leave with common mental disorders (CMDs), focusing beyond illness and towards mental health, this thesis evaluates an eHealth intervention ...

• lntestinal health after pelvic radiotherapy - towards understanding persisting pathophysiological mechanisms 

  Devarakonda, Sravani

  Pelvic cancer survivors struggle with life-long symptoms caused by radiotherapy. Many pelvic cancer survivors live with a constant fear of leaking faeces and the need to always have a toilet within reach. Some of these ...

• Neutrophil Serine Proteases in Health and Disease 

  Sanchez Klose, Felix P

  Neutrophils are filled with many antimicrobial agents, including the neutrophil serine proteases (NSPs); a group of proteases including Elastase, Proteinase 3, and Cathepsin G. Synthesized as inactive proforms, the NSPs ...

• ReCREating BRAF-driven thyroid and lung cancer in mice 

  Schoultz, Elin

  Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a 3:1 female/male incidence. PTC is caused by oncogenic BRAF mutation encoding BRAFV600E in 50% of cases. Prognosis is mostly excellent post- ...

• Cerebral Venous Thrombosis - Complications and Outcomes 

  Lindgren, Erik

  Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke, which predominantly affects working-aged adults and particularly women. The clinical course is highly miscellaneous. Data from large cohorts are scarce ...

• Understanding mental illness and promoting mental health -Experiences of Exhaustion Disorder and Effects of a Person-Centred eHealth Intervention 

  Alsén, Sara

  Health is subjective, involving the whole person, and cannot be determined by others. It is a resource in life, not merely the absence of disease and illness. Common mental disorders (CMDs), including stress-related ...

• Deregulated epigenetics and cancer stem cells in brain tumours 

  Wenger, Anna

  Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, ...

• Defining the clinical usefulness of vertebral fracture assessment 

  Johansson, Lisa

  Objective: Vertebral fractures (VFs) are the most common osteoporotic fracture and among the strongest predictors for future fracture. VFs can be identified by vertebral fracture assessment (VFA) from lateral spine imaging ...

• Acromegaly - Mortality, Morbidity and Treatment Patterns 

  Esposito, Daniela

  Background: Acromegaly is a systemic disease associated with multiple comorbidities. The clinical characteristics of acromegaly develop insidiously over several years and the diagnosis is usually delayed. Progress has been ...

• Optimisation of radionuclide therapy by reduction of normal tissue damage 

  Andersson, Charlotte

  Background:177Lu-octreotate is used to treat patients with neuroendocrine tumours (NETs) often resulting in prolonged life and better quality of life, but is today seldom a cure for these patients. Optimisation of ...

• Chronic Achilles Tendon Rupture - Perspectives on outcomes after surgical treatment and rehabilitation 

  Nordenholm, Anna

  Chronic Achilles tendon rupture (CATR) is a rupture of the Achilles tendon for which adequate diagnosis and treatment has been delayed after index injury. In this thesis defined as 4 weeks or more. The delay is commonly ...

• New Risk Factors in Poststroke Epilepsy 

  Eriksson, Hanna

  The overall aim of the present research was to identify new risk factors for poststroke epilepsy (PSE). Specifically, we wanted to assess the impact of having a first-degree relative with epilepsy on PSE risk (Paper I), ...

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