Sahlgrenska Academy / Sahlgrenska akademin
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Chronic rhinosinusitis - Epidemiological studies on occupational exposure, obesity and sick leave
(2025-02-07)Chronic rhinosinusitis (CRS) is a disease characterised by chronic inflammation of the mucosa lining the nose and paranasal sinuses, with a significant negative impact on patients’ quality of life. CRS affects around 11% ... -
Unintended pregnancy and early medical abortion
(2025-02-07)Background: Very early medical abortion (VEMA) is performed before the confirmation of intrauterine pregnancy (IUP) by ultrasound. Over the past 25 years, more women have sought abortions earlier in pregnancy. Concerns ... -
Philadelphia-Negative Myeloproliferative Neoplasms: Diagnostic Insights, Genetic Factors and Vascular Impact on Survival
(2025-02-06)The thesis addresses Philadelphia-negative myeloproliferative neoplasms (MPNs), a group of clonal hematopoietic stem cell disorders encompassing polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis (MF) ... -
Weaving the Threads of Memory: How Pre-existing Immunity Shapes B Cell Responses to Influenza A Virus
(2025-02-05)Influenza A virus (IAV) poses a persistent global health threat due to its ability to evolve rapidly, requiring annual updates to seasonal vaccines. Despite significant advancements, a universal vaccine capable of providing ... -
Early mobilization in intensive care Experiences of patients and healthcare professionals, and a comparison of physiological responses during mobilization
(2025-01-30)Introduction. Early mobilization in intensive care is frequently used to prevent physical and psychological complications, with promising results. As its significance becomes increasingly apparent, understanding the ... -
Arbete i kyla med sjukdom
(GÖTEBORGS UNIVERSITET, 2024-12-10)Det övergripande syftet med denna narrativa kunskapsöversikt var att beskriva hur hälsorisker förknippade med arbete i kyla påverkas av ålder och sjukdom. En systematisk litteratursökning genomfördes i Medline, Embase och ... -
Biomarkers in relation to outcome after severe traumatic brain injury and severe covid-19
(2025-01-29)Intro: A severe traumatic brain injury (sTBI) causes neuronal and astrocytic injuries, initiating a cascade of mechanisms further exacerbating the damage. Similarly, a severe covid-19 infection can cause brain damage by ... -
Palliative care consultation services - bridging gaps with general healthcare teams
(2025-01-24)Palliative care consultation services support palliative care practice within healthcare settings outside of specialised palliative care. The overall aim of this thesis was to further our understanding of how palliative ... -
Ultrasensitive nucleic acids analysis using digital sequencing
(2025-01-24)Liquid biopsies offer a minimally invasive and affordable procedure to obtain valuable clinical insights through biomarker analysis that can aid to manage the care of different diseases and health conditions. Analysis of ... -
Exploring the source of human cardiac regeneration
(2025-01-21)The human heart is known to have limited regenerative capacity, and the source of new cardiomyocytes remains enigmatic. The existence of stem cells in the adult human heart has been a topic of debate. Recently, a potential ... -
Evaluating Virtual Reality and Artificial lntelligence as Emerging Digital Tools for Mental Health Care
(2025-01-16)This thesis evaluates the potential of Virtual Reality (VR) and Artificial Intelligence (AI), specifically Natural Language Processing (NLP) and Large Language Models (LLMs), as emerging tools for mental health care. VR ... -
Drug interactions in healthcare - Knowledge resources and clinical management
(2025-01-14)Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ... -
Gravitostat: A Homeostatic Regulator of Body Weight
(2025-01-14)This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ... -
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ... -
The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system
(2025-01-08)Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ... -
Cardiopulmonary Phenotyping during Sleep - Innovative Signal Processing for Precision Medicine in Sleep Apnea
(2024-12-18)Background: Obstructive sleep apnea (OSA) is one of the most common sleep disorders with a significant impact on public health. Various studies suggest that the contemporary methods of clinical sleep medicine are ... -
Translational studies to understand myocardial stunning in acute myocardial infarction
(2024-12-18)Myocardial stunning is a reversible contractile dysfunction that persists despite the resolution of myocardial ischemia. It is commonly associated with acute myocardial infarction. However, myocardial stunning also occurs ... -
Radiation-induced Dysphagia: Intervention and Assessment Tools for Head and Neck Cancer
(2024-12-16)Abstract The aim of the thesis was to evaluate the effect of two interventions to prevent or reduce complications of radiation-induced swallowing and mouth opening difficulties among HNC patients. An additional aim was ... -
Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Management of pregnancy of unknown location. Diagnostic protocols, clinical outcomes and psychosocial aspects
(2024-12-10)Background: Ectopic pregnancy (EP) is the leading cause of pregnancy-related first trimester mortality. Many EP remain undiagnosed beyond an initial transvaginal ultrasound assessment. Noninvasive diagnosis of EP in women ...