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Image-Based Dosimetry in Targeted Radionuclide Therapy with Terbium-161: From Technical Foundations to Clinical Application
(2025-05-15)This work explores SPECT/CT-based quantification of the novel therapeutic radionuclide terbium-161 (161Tb). The interest in 161Tb stems from its substantial emission of low-energy conversion and Auger electrons, hypothesized ... -
Surface electromyography for improving upper limb function after stroke - Development of new rehabilitation tools
(2025-05-15)Background: Upper limb impairment is a major consequence after stroke, significantly affecting independence and quality of life. Various rehabilitation technologies have been developed to improve upper limb function, ... -
Endovascular shunting techniques in vascular surgery
(2025-05-13)Abstract Background: Acute tissue ischaemia can lead to significant tissue damage and, in severe cases, permanent loss of organ or limb function. Temporary arterial shunting is an established technique to mitigate ... -
Exploring the genetics of hereditary cancer, with a focus on colorectal cancer
(2025-05-13)Hereditary cancer syndromes are characterized by an inherited genetic predisposition that increases an individual's risk of developing specific types of cancer. Hereditary cancer accounts for about 5-10 % of all cancer ... -
Simulated Daylight Photodynamic Therapy for Superficial Basal Cell Carcinoma and Actinic Keratoses
(2025-05-13)The overall aim of this thesis was to evaluate simulated daylight photodynamic therapy (SDL-PDT) for the treatment of actinic keratoses (AKs) and superficial basal cell carcinoma (sBCC). The included studies assessed this ... -
Enteric infections in Rwandan children under 5 years
(2025-05-13)Infectious diarrhea is a main cause of illness and death among children in poor countries, and enteric infections may also cause stunting as a result of impaired uptake of nutrients. This thesis investigated a broad range ... -
From extra-skeletal bone growth to re-osseointegration: Osteoinduction and mechanical disruption in bone repair
(2025-05-13)The effort to preserve the integrity and function of the skeletal system has driven scientific innovation for centuries. Clinical challenges—such as tooth loss, joint failure, limb amputation, and large bone voids caused ... -
Enhancing the Management of High-Risk Basal Cell Carcinoma
(2025-05-13)Basal cell carcinoma (BCC) is the most common skin cancer, with over 71,000 new cases in Sweden in 2023. High-risk facial BCCs are most appropriately treated with Mohs micrographic surgery (MMS), which is considered the ... -
NOX-inflicted oxidative stress in neurodegeneration and inflammation
(2025-05-13)Further understanding of mechanisms that promote neuronal decay in neurodegenerative diseases may pave the way for new therapies. Aberrant activation of the reactive oxygen species (ROS)-generating enzyme NADPH oxidase 2 ... -
Computational phenotyping of obstructive airway diseases and allergy
(2025-05-13)Allergy and obstructive airway diseases, e.g., asthma, are common and may inflict substantial hardship. They are also interlinked and heterogeneous in their clinical presentations (phenotypes). Artificial intelligence (AI) ... -
The role of the gut microbiota and frailty on bone metabolism, and the risk of injurious falls and fractures
(2025-05-13)Aging is intrinsically linked to musculoskeletal decline, culminating in increased risk of frailty, falls, fractures, and associated morbidity and mortality. This thesis investigates the association between gut microbiota ... -
Allergic Rhinitis in Childhood and Young Adulthood: Epidemiology, Prevalence and Risk Factors
(2025-05-08)Background and Aim: Allergic rhinitis (AR) is a common chronic condition among young people. This thesis examines the prevalence, risk, and protective factors of AR in 12-year-olds. It also compares questionnaire-derived ... -
Comparisons between new and established methods for analysis of response to treatment in acute leukemia
(2025-05-08)Acute leukemia is a severe hematologic malignancy that affects both adults and children. Although prognosis has improved over recent decades, relapse remains one of the major challenges. A key reason for relapse is that ... -
Personalized analysis of circulating tumor DNA in childhood malignancies
(2025-05-08)Circulating tumor DNA (ctDNA) analysis has emerged as a powerful technique for precision medicine in pediatric oncology. ctDNA refers to small fragments of tumor-derived genetic material that are released into the ... -
Adolescent-onset anorexia nervosa in the acute stage and after 30 years
(2025-04-29)Anorexia nervosa (AN) is a severe eating disorder (ED) that predominantly affects females in early adolescence. The overarching aim of this thesis has been to examine individuals with adolescent-onset AN in the acute stage, ... -
On COVID-19-Associated Central Nervous System Complications
(2025-04-29)The acute and long-term neurological impacts of COVID-19 have raised important concerns regarding the involvement of the central nervous system (CNS) in SARS-CoV-2 infection. This thesis examines the biochemical and ... -
Birth weight and childhood overweight - exploring parental influences and future risk of coronary heart disease
(2025-04-29)Overweight and obesity now affect individuals of all ages in all parts of the world. Obesity leads to individual suffering as well as increased risk of future disease and premature death from several causes, among which ... -
Utmaningar och förbättringsmöjligheter för MR-faskontrast vid diagnostik av kronisk aortainsufficiens
(2025-04-29)Aortic valve regurgitation (AR) occurs when the valve fails to close properly, allowing blood to flow back into the left ventricle during diastole. This puts extra strain on the heart and, over time, can lead to damage ... -
P-tau212: a novel biomarker for tau pathology in specific neurodegenerative diseases
(2025-04-25)Tau protein is involved in multiple physiological processes in the central nervous system, one of which is microtubule stabilization. Post-translational modifications of tau, such as phosphorylation strictly regulate this ...
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