• Know your enemy or find your friend?-Induction of IgA at mucosal surfaces 

  Bemark, Mats; Angeletti, Davide (2021)

• Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response 

  Glaros; Emmanouilidi, Aikaterini; Angeletti, Davide; Et.al (2021)

  Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early ...

• Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection 

  Yewdell, W. T.; Smolkin; Belcheva; Mendoza; Michaels; Cols; Angeletti, Davide; Yewdell; Chaudhuri (2022)

  Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier ...

• Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells 

  Mathew, Nimitha Rose; Jayanthan, Jayalal; Smirnov, Ilya; Robinson, Jonathan L; Axelsson, Hannes; Sowdamini Nakka, Sravya; Emmanouilidi, Aikaterini; Czarnewski, Paulo; Yewdell, William T; Schön, Karin; Lebrero-Fernandez, Cristina; Bernasconi, Valentina; Rodin, William; Harandi, Ali M; Lycke, Nils Y; Borcherding, Nicholas; Yewdell, Jonathan W; Greiff, Victor; Bemark, Mats; Angeletti, Davide (2022)

  B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, ...

• Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality 

  Hammarstrand, Casper

  Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ...

• The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level 

  Tian, Yarong

  Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. The risk ...

• Dupuytrens sjukdom i relation till exponering för handöverförda vibrationer 

  Nilsson, Thor; Wahlström, Jens; Reierth, Eirik; Burström, Lage (Samhällsmedicin och folkhälsa, 2022-05-30)

  Kunskapsöversikten syftar till att specifikt besvara frågan om risk för Dupuytrens sjukdom i relation till exponering för handöverförda vibrationer. Litteraturgenomgången följde PRISMAs systematiska metod omfattande databaserna ...

• Interprofessional Teamwork in the Emergency Department - Communicating for Patient Safety 

  Milton, Jenny

  Interprofessional teams may improve patient safety through successful communication and effective teamwork. However, ineffective teamwork occurs despite the implementation of various strategies and can compromise patient ...

• Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link 

  Gravina, Giacomo

  Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher ...

• The role of galectin-1 in type 2 diabetes. Clinical and experimental studies 

  Fryk, Emanuel

  Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and ...

• lnvestigating intestinal smooth muscle dysfunction in the 6-OHDA rat model of Parkinson's disease 

  Murillo Angarita, Maria del Pilar

  The neurodegenerative progression of the nigrostriatal pathway in Parkinson’s disease (PD) entails the appearance of motor and nonmotor symptoms. Nonmotor symptoms are common, having a negative impact on the quality of ...

• Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats 

  Danielsson, Klara

  The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral ...

• Viral proteins as serological antigens - Development and clinical applications 

  Persson Berg, Linn

  Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological ...

• Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods 

  Svedberg, Marcus

  Background: Cystic Fibrosis (CF) is an inherited progressive disease that causes severe damage to the airways and other organs of the body. Many methods are available to track CF lung disease but longitudinal data are ...

• The endocrine system in the progression of mild cognitive impairment to dementia 

  Quinlan, Patrick

  Background and aims: Endocrine alterations have been related to cognitive decline, but the role of hormones may vary along the progression to manifest dementia. The overall aim of this thesis was to assess whether thyroid ...

• Exploring small airways using breath analyses 

  Viklund, Emilia

  Background: Airway irritants such as allergens, tobacco smoke and viruses may cause damage in the small airways, usually undetected with routine diagnostic methods. Analyses of endogenously produced nitric oxide (NO) and ...

• Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin 

  Hansson, Erik

  This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ...

• Nutritional impact on health in patients with Rheumatoid Arthritis 

  Hulander, Erik

  Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ...

• Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer 

  Keane, Simon

  Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ...

• lntestinal microenvironment, epithelial barrier interactions and human milk oligosaccharide supplementation in irritable bowel syndrome 

  Iribarren Gómez, Cristina

  Alterations of the microbiota-host interactions at the mucosal border may be of importance in symptom generation in irritable bowel syndrome (IBS), a disorder of gut-brain interaction. Hence, microbiota-targeted interventions ...

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