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Respirable crystalline silica
(GÖTEBORGS UNIVERSITET, 2024-09-10)Crystalline silica is abundant in nature and used in a variety of industries, e.g., mining, farming, construction, foundry processes and production of glass, artificial stone, ceramics and cement. When cut or crushed, dust ... -
Profiling Circulating T cells and Tumor Landscape for Predicting Responses to PD-1 blockade in Patients with Non-Small Cell Lung Cancer
(2024-09-05)Immune checkpoint blockade (ICB) has significantly improved outcomes in non-small cell lung cancer (NSCLC), yet only a subset of patients achieves durable responses. This underscores the need for effective methods to assess ... -
Food-related symptoms, dietary interventions, and importance of the gut microenvironment in IBS
(2024-08-29)Irritable bowel syndrome (IBS) is characterized by chronic gastrointestinal (GI) symptoms, including abdominal pain and altered bowel habits i.e., constipation and diarrhea. The pathophysiology is complex and multifactorial ... -
Prostate Biopsy - Cancer detection and risk of complications
(2024-08-29)The overall aim of this thesis was to investigate if a sampling protocol with anterior biopsies of prostate increase cancer detection at first repeat biopsy, to evaluate if a clinical routine with urine culture prior to ... -
Biomaterial-induced inhibition of Staphylococcus aureus biofilm formation
(2024-08-23)Biomaterial-associated infection (BAI) is a severe complication linked to medical device implantation, causing significant patient suffering and high healthcare costs. The pathogenesis of BAI is complex and not fully ... -
lnvestigating the functions of Anaplastic Lymphoma Kinase in neuronal tissues
(2024-08-23)Receptors play an important role in cell-to-cell communication and are critical to the development and homeostasis of multicellular organisms. Anaplastic Lymphoma Kinase (ALK) is an evolutionary conserved receptor tyrosine ... -
Thoracic Mobility in Cystic Fibrosis Care
(2024-08-19)Introduction: Cystic fibrosis (CF) is an incurable and highly life-limiting hereditary disease. However, due to significant medical advancements over recent decades, life expectancy has risen to close to 50 years. As such, ... -
Influence of Estrogen on Sex Bias in Inflammation
(2024-08-19)The aim of this thesis was to investigate mechanisms underlying sex differences in inflammation and disease. In particular, the role of estrogen in regulating these mechanisms was explored. A secondary aim was to investigate ... -
Microbiota and Bone - Treatment Studies of Probiotics and Synbiotics on Osteoporosis in Mice
(2024-08-19)Osteoporosis is a disease with low bone mass and an increased fracture risk. One in two women and one in four men in Sweden will experience an osteoporotic fracture. The aim of this thesis is to identify new gut microbiota-based ... -
On targeting host-pathogen interaction to prevent biomaterial-associated infections on titanium implants
(2024-08-15)The rising use of implants, driven by an ageing global population and conditions such as osteoporosis and osteoarthritis, highlights the urgent need to address implant-related complications. Despite high success rates, ... -
Comparative studies in the clinical and molecular features of breast cancer and brain metastases
(2024-08-15)We hope to understand better the unique pattern of CNS metastases from breast cancer, hopefully adding to the field and ultimately increasing the chances of preventing and treating them. In this thesis, we approached the ... -
Advancing Precision Medicine in Type 2 Diabetes through Machine Learning: Treatment Comparisons and Risk Predictions
(2024-06-05)Precision medicine holds significant promise for improving the management of type 2 diabetes, yet its implementation faces several challenges. This thesis aims to address existing gaps in precision medicine for type 2 ... -
Physical Activity Before and After Stroke - Examining Stroke lncidence and Outcomes
(2024-05-24)Background: Stroke is a leading cause of death and disability worldwide. A physically active lifestyle may prevent stroke and decrease the consequences of a stroke. Physical activity is also an important component in ... -
Complications and side effects of Robot Assisted Radical Prostatectomy with focus on anastomotic stenosis and urinary incontinence
(2024-05-23)This thesis quantifies the risk of two postoperative complications: symptomatic anastomotic stenosis and post-prostatectomy incontinence (PPI), following radical prostatectomy. We aim to identify and explore the risk factors ... -
Sport participation after paediatric and adolescent ACL injury
(2024-05-22)The incidence of anterior cruciate ligament (ACL) injuries in pediatric and adolescent patients is increasing. ACL reconstruction at a young age has been identified as a risk factor for an ACL revision later on, and studies ... -
Pregnancy complicated by preeclampsia. A closer look at cognitive function, partners' experiences and maternal mental health
(2024-05-22)Becoming pregnant is a turning point in life. Acting like a catalyst for the parents-to-be, most pregnancies evolve without complications. However preeclampsia, a pregnancy induced syndrome, affects 3-5% of all pregnancies. ... -
Peri-operative management, surgical outcome and prognostication in pheochromocytoma and paraganglioma
(2024-05-22)Pheochromocytomas and paragangliomas (PPGL) are rare tumors originating from the adrenal medulla and paraganglionic tissue. Although mainly non-metastatic they can still be life threatening due to excretion of catecholamines ... -
Midwifery care providers' competencies in sub-Saharan Africa and global perinatal health outcomes
(2024-05-20)Background: Maternal and newborn mortality and morbidity remain critical global health issues, particularly in sub-Saharan Africa where many countries are struggling to meet the maternal and newborn related Sustainable ... -
Survival, prognostication and secondary prevention in cardiac arrest
(2024-05-17)Background: Sudden Cardiac Arrest (SCA) is a highly lethal medical emergency, caused by an abrupt cessation of cardiac function. Despite extensive research efforts, increased public awareness and systematic healthcare ... -
Improving Disaster Management in Saudi Arabia Through Collaborative Exercises and Education for Nurses and Other Healthcare Workers
(2024-05-17)Disasters have increasingly been shown to have consequences that require swift and effective action from both authorities and society. Specifically, coordination, collaboration, and cooperation have proven to be recurring ...