• lncidence of Colorectal Cancer and Comparisons of Outcomes after Minimally Invasive and Open Surgery 

  Petersson, Josefin (2023-12-07)

  Aim: Surgery remains the mainstay of treatment for colorectal cancer. The aim of this thesis was to determine the overall incidence of colorectal cancer in Sweden over time and to evaluate surgical treatment comparing ...

• Children who screen positive for language delay but not autism: from 2.5 to 6 years of age 

  Schachinger Lorentzon, Ulrika (2023-12-05)

  Background: Language disorders (LDs) are prevalent, affecting approximately 10% of children. Among them, 7.5% have developmental language disorder (DLD), while 2.5% have LD associated with a known medical condition. In ...

• Endogenous and microbial modulators of inflammation 

  Kraft, Jamie Dale (2023-12-05)

  Cardiometabolic disease is characterized by dysregulated, chronic inflammation, that may result from impaired resolution pathways or alterations in the gut microbiota. Thus, restoring specialized pro-resolving mediators ...

• Diet as a complementary therapy in Rheumatoid Arthritis - On the menu: An anti-inflammatory portfolio diet 

  Turesson Wadell, Anna (2023-11-27)

  Over the last two decades, pharmacological treatment in rheumatoid arthritis (RA) has evolved remarkably and is essential to suppress disease progress. Still, it often fails to provide satisfactory symptom relief suggesting ...

• lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation 

  Elvborn, Mikael (2023-11-24)

  Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. ...

• New sensitive and specific methods for sex steroid measurements in rodent serum and tissues 

  Nilsson, Maria (2023-11-23)

  Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular ...

• Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses 

  Rezapour, Azar (2023-11-22)

  Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies ...

• Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis 

  Gorreja, Frida (2023-11-22)

  Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune ...

• The interplay between bile acids and gut microbiota in metabolic and hepatobiliary disease 

  Sjöland, Wilhelm (2023-11-21)

  The gut microbiota, a metabolic regulator, orchestrates the production of bioactive metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut microbiota composition are linked to metabolic ...

• The AfterBabyBodyStudy: Muscular changes, exercising, and activity limitations and their associations with pelvic girdle pain and urinary incontinence in the postpartum period 

  Vesting, Sabine (2023-11-21)

  Aim: Pregnancy and childbirth can lead to several symptoms, changes in the pelvic floor muscles and a diastasis recti abdominis (DRA). This thesis aimed to assess and explore stress urinary incontinence, vaginal heaviness, ...

• Acute Achilles tendon rupture: The impact of physiological and psychological factors on function and return to activity 

  Jónsdóttir, Unnur (2023-11-17)

  Unfortunately, there is no guarantee of a full return to physical activity after an Achilles tendon rupture. About 20% of those who sustain the injury do not return to their previous level of physical activity. Although ...

• Venous thromboembolism: Risk factors, comorbidities, and treatment-associated risk of bleedings 

  Glise Sandblad, Katarina (2023-11-16)

  Background: Venous thromboembolism (VTE) is the third most common cardiovascular disease, consisting mainly of deep vein thrombosis (DVT) and pulmonary embolism (PE). Since VTE often is a preventable disease, knowledge of ...

• Sex differences in behavior and metabolism 

  Maric, Ivana (2023-11-16)

  Men and women exhibit distinct illness patterns and disparate responses to pharmacotherapies. However, there is a scarcity of preclinical studies that systematically compare the sexes. The overarching aim of this thesis ...

• Physical activity and stroke - Associations and patient experiences 

  Reinholdsson, Malin (2023-11-15)

  Background: Insufficient physical activity is a global problem and a risk factor for stroke. Furthermore, physical activity is often reduced after stroke, and many patients are physically inactive in stroke units. Aim: ...

• Constructing patient safety. Exploring unsafe care events in hospital settings as reported by patients, relatives, and healthcare professionals 

  Gyberg, Anna (2023-11-15)

  The conditions of hospital care are continuously transformed with advances in medicine and technology, and with organizational alterations influenced by the changing needs of the population. As these conditions affect ...

• Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT 

  Eckernäs, Emma (2023-11-15)

  N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ...

• Young Children with Autism in a Multiethnic Immigrant Population. Prevalence, Feeding Disorders, Early Detection, and Intervention 

  Linnsand, Petra (2023-11-14)

  Background: Autism is a neurodevelopmental condition characterized by a pattern of major impairments in social communication and behavioural/sensory problems, with high rates of coexisting neurodevelopmental and medical ...

• Functional characteristics of periodontitis and peri-implantitis lesions in humans 

  Dionigi, Carlotta (2023-11-14)

  In the current series of studies functional characteristics of periodontitis and peri-implantitis lesions in humans were investigated. Cell markers for antimicrobial activity were used to evaluate differences between ...

• Neoehrlichiosis - latent infection of endothelium and immune defense 

  Wass, Linda (2023-11-14)

  This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense ...

• Cellular and molecular mechanisms of kidney injury and regeneration 

  Kha, Michelle (2023-11-13)

  The prevalence of kidney disease is constantly increasing with about 600 million people afflicted globally. Kidney disease may result in end stage renal disease, a condition that requires renal replacement therapy in the ...

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