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Cholinergic modulation of dopamine-related effects of ethanol in the rat
(2024-04-25)Alcohol use disorder is associated with serious medical consequences leading to preterm death. Alcohol activates the brain reward system, leading to an increase of extracellular dopamine (DA) levels in the nucleus accumbens ... -
Congenital heart disease and cancer: Cancer risk, risk factors and outcomes after cancer diagnosis
(2024-04-25)Background: Congenital heart disease (CHD) is the most common congenital defect. The aim of this thesis was to study whether there is a higher cancer risk in CHD patients than in the general population (papers I and II), ... -
Outcomes of inguinal hernia surgery : Combining and exploring data from national registers in Sweden
(2024-04-25)Surgery for inguinal hernia is one of the most frequent operations in the world. In this thesis, data from the Swedish Hernia Register are combined with results from patient related outcome measures as well as with other ... -
New-onset atrial fibrillation after coronary surgery: epidemiology, risk factors and long-term prognosis
(2024-04-25)Background and aim: New-onset postoperative atrial fibrillation (POAF) is common following coronary artery bypass grafting (CABG). Evidence on its prognostic implications, risk-stratification methods, and factors influencing ... -
Optimizing the early diagnosis process of urinary bladder cancer. On standardized care pathway, computed tomography, artificial intelligence, and a newly developed urine-based cancer marker
(2024-04-25)The thesis contains of five articles in three different subprojects. The overall aim of this thesis is to investigate the development of the investigation of macroscopic hematuria over time, the effects of this development ... -
The impact of family, community, and chronic conditions on late-life depression in China
(2024-04-24)Background: With the increasing ageing population in China, investigating risk factors for late-life depression is of particular importance. This thesis aims to investigate how family dynamics, community factors, and ... -
Psychological outcomes during rehabilitation after ACL reconstruction - and implications for second ACL injury
(2024-04-24)An anterior cruciate ligament (ACL) injury is a common knee joint injury. An ACL injury is typically managed through surgical reconstruction of the ligament, followed by rehabilitation. For patients treated with ... -
Objective and subjective outcomes from Bone Conduction Hearing Devices
(2024-04-23)Bone conduction hearing devices are generally the best treatment for patients whit a conductive or mixed hearing loss, or a single sided deafness, that cannot use conventional hearing aids. The aim of this thesis was to ... -
Spinal Foraminal Stenosis - Novel methods and MRI in functional positions to improve diagnostics
(2024-04-22)Background: Symptomatic spinal foraminal stenosis can cause radiculopathy, sensory disruptions, and motor weaknesses in the extremities. These symptoms typically present intermittently and are closely linked to various ... -
Adipokines and cell metabolism in early rheumatoid arthritis
(2024-04-22)This thesis aimed to investigate the role of adipokines as adiponectin, leptin, and resistin, as well as cell metabolism in rheumatoid arthritis (RA). We assessed whether these adipokines are associated with inflammation ... -
Predictors of severe kidney disease in long-term lithium treatment
(2024-04-22)The thesis aims to advance the understanding of severe chronic kidney disease in lithium-treated patients through four observational studies in which subjects were recruited from the Sahlgrenska University Hospital laboratory ... -
Behavioral Intervention for Improved Oral Hygiene in Adolescents - A Person-Centered and Theory-Based Approach
(2024-04-18)To educate and enhance patients’ motivation for adequate oral hygiene, that is self-performed periodontal infection control, is essential in the prevention of periodontal disease. Surveys have shown poor oral hygiene ... -
Molecular mechanisms of human presynapse assembly - role of liprin-alpha proteins in synapse organization and neurological disease
(2024-04-18)Synapses are the essential transmission units of neuronal circuits and represent the cornerstone of our unique cognitive abilities. During synapse formation, contact between two neurons induce the assembly of pre- and ... -
Superparamagnetic iron oxide for sentinel lymph node biopsy
(2024-04-18)Superparamagnetic iron oxide nanoparticles (SPIO), used as a tracer for sentinel lymph node (SLN) detection, offer several logistical benefits over the standard method using radioactive technetium-99m and blue dye. The ... -
Assessment and management of respiratory tract infections in primary care
Background: Respiratory tract infections (RTIs) are common causes of primary care visits and range from benign to life-threatening. Avoiding the overuse of antibiotics, which can lead to antimicrobial resistance, necessitates ... -
Relationship of Surgical Technique and Bony Morphology on Anterior Cruciate Ligament (ACL) Failure- Effect of Surgical Volume on Surgical Technique
(2024-04-15)Anterior cruciate ligament (ACL) injuries are becoming increasingly common and can have a detrimental effect on patients and their activities. Anatomic ACL reconstruction remains the gold standard for treatment. While ... -
Endovascular repair of aortic disease. Clinical and radiological outcomes
(2024-04-11)Background: Endovascular repair of aortic disease has improved but long-term outcome is questioned. Aims: To evaluate radiological and clinical outcome of endovascular aortic repair. Specifically: I. To evaluate if expansion ... -
The Translocation t(7;12)(q36;p13) in Childhood Acute Myeloid Leukemia
(2024-04-11)The reciprocal translocation t(7;12)(q36;p13) gives rise to acute myeloid leukemia (AML) in infants and very young children. A fusion transcript MNX1::ETV6 is sometimes detected and an aberrant expression of MNX1 is ... -
lnfluence of stem design on Total Hip Arthroplasty. Clinical and radiological assessment based on randomized controlled trials and register data
(2024-04-09)Since the 1960s, total hip arthroplasty has revolutionized the care of patients with end-stage osteoarthritis. Results after surgery using contemporary implants are usually good. Nevertheless, new implants are constantly ... -
Arbetsrelaterad hudcancer
(GÖTEBORGS UNIVERSITET, 2024-03-28)Den första yrkesrelaterade cancern som upptäcktes var skivepitelcancer på huden på pungen hos engelska sotare som först beskrevs 1775. Under senare delen av 1800-talet och 1900-talet fann man att också mineraloljor och ...