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Arbetsrelaterad hudcancer
(GÖTEBORGS UNIVERSITET, 2024-03-28)Den första yrkesrelaterade cancern som upptäcktes var skivepitelcancer på huden på pungen hos engelska sotare som först beskrevs 1775. Under senare delen av 1800-talet och 1900-talet fann man att också mineraloljor och ... -
Perinatal brain damage-phagoptosis and neuroprotection
(2024-03-27)Background: Neonatal encephalopathy is a serious outcome in term infants affecting 1-2/1000 live births and is often caused by perinatal hypoxia-ischemia (HI). However, brain injury is multifactorial and infection in the ... -
Physiotherapist as primary assessor of knee osteoarthritis in primary care - Evaluation of patients’ self-assessment, preferences, quality of life, and health economy
(2024-03-27)Aim: The purposes with this thesis was to evaluate the feasibility of 30-second chair stand test as a self-test, and to investigate the effects of direct access to physiotherapist on costs and health in people with knee ... -
Epidemiological aspects of health and work ability in the Swedish workforce
(2024-03-25)Background: Many working-age individuals suffer from health issues, impacting their work ability and potentially leading to early workforce exit. More understanding of individual and occupational factors influencing work ... -
Long-term Bowel and Stoma Function Following Colorectal Cancer Surgery
(2024-03-25)Aim: The aim of this thesis was to explore bowel and stoma function following colorectal cancer surgery, to investigate associated distress and identify possible risk factors. Methods: Papers I, II, and IV were based on ... -
The role of insulin-like growth factor-l in Alzheimer's disease and vascular dementia
(2024-03-25)Background and purpose: Insulin-like growth factor-I (IGF-I) is involved in normal brain function, but little is known whether IGF-I activity affects the cognitive continuum of dementing disorders. The overall purpose of ... -
lnduction Therapies in Multiple Sclerosis - Clinical and immunological follow-up
(2024-03-21)Multiple sclerosis (MS) is a chronic disease that damages the central nervous system. Its pathophysiology is complex, and consists of inflammation and degeneration from the disease onset. The treatment of MS has continuously ... -
On incidence, diagnostic algorithms and in-depth characterisation of thyroid cancer
(2024-03-20)Background: Thyroid cancer (TC) incidence has increased dramatically. Overzealous detection of subclinical disease is the most common explanation. However, whether the higher rate of diagnosis of subclinical disease might ... -
Polycystic ovary syndrome in women with severe obesity - effects of a 12-month weight loss intervention
(2024-03-19)Background: Polycystic ovary syndrome (PCOS) affects one out of eight women and is associated with reproductive, metabolic, and psychiatric features. There is a strong association with obesity but studies on PCOS in women ... -
Humoral lmmune Response with Focus of lgG Glycosylation -In murine models
(2024-03-14)The humoral immune system orchestrates a vital defense mechanism through the secretion of antibodies, especially Immunoglobulin G (IgG), which actively targets and neutralizes foreign particles and pathogens. Glycosylation ... -
NK cell recognition of malignant cells - a CRISPR approach to define novel mediators
(2024-03-14)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system, capable of eliminating malignant cells. Their activity is intricately regulated through a balanced interplay between activating and inhibitory ... -
Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
A treatment seeking population with Gambling Disorder - Internet treatment, severity and gender
(2024-02-21)Gambling is a common pastime all over the world, but can become harmful in excess and can even develop into an addictive behavior, a Gambling Disorder (GD). The aim of this thesis was to contribute to the clinical understanding ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Trends and determinants for graft survival among kidney transplanted patients in Sweden
(2024-02-07)According to literature, even after a successful kidney transplantation approximately 50% of the patients risk losing the transplant within ≈15 years. A return to dialysis or a new transplantation is then necessary. ... -
Speech production and literacy in students with intellectual disabilities and communication difficulties
(2024-02-07)Many individuals with intellectual disabilities have difficulties with spoken communication and literacy learning leading to vulnerability. It has been suggested that interventions to promote reading in this group not only ... -
Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy
(2024-02-07)Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ...