Sahlgrenska Academy / Sahlgrenska akademin
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Novel signaling and treatment regimes in Anaplastic Lymphoma Kinase driven neuroblastoma models
(2024-11-04)In this thesis we aimed to unravel the importance of Alkal2 in neuroblastoma with the aid of preclinical murine models. We tested the hypothesis that Alkal2 can potentiate murine MYCN-driven neuroblastoma in absence ... -
Cancer genetic risk assessment - Studies on genetic testing, genetic counselling and risk management
(2024-10-31)The assessment for hereditary cancer is a consultative service in clinical genetics and cancer care that includes genetic testing and genetic counselling for patients and their relatives, defining elevated cancer risk, and ... -
Person-centered collaboration in the sick leave and rehabilitation process - in a primary care context
(2024-10-31)Aim: This thesis focuses on chronic illness and long-term health-related impairments in work ability, with the overarching aim of expanding knowledge about the sick leave and rehabilitation process (SRP) to support primary ... -
Evaluation of long-term outcomes after anterior cruciate ligament reconstruction. Operative methods, clinical and radiological findings, and their relationship to patient-reported acceptable knee function
(2024-10-29)The overarching theme of this thesis was to evaluate long-term clinical, subjective and radiological results after anterior cruciate ligament (ACL) reconstruction in regard to: different surgical methods, specifically ... -
Primary Aldosteronism; a growing challenge
(2024-10-29)Primary aldosteronism (PA), caused by excessive aldosterone production, is a frequently overlooked cause of hypertension. Cardiovascular complications are more common in patients with PA than patients with essential ... -
Cardiometabolic disease and cancer. Effects of body weight and diabetes
(2024-10-23)Background: The rise in overweight and obesity rates is associated with an increase in various forms of cardiovascular disease (CVD) and cancer. Moreover, an increasing proportion of young people with diabetes have type 2 ... -
Spiritual Care Unveiled - Religious Literacy in Palliative Care
(2024-10-23)Sweden is portrayed as being multicultural and multireligious and at the same time, significantly impacted by secularization and simultaneously highly influenced by secular values. This diversity necessitates that society ... -
Aortic Dissection in Turner Syndrome - Risk factors and Long-term Outcomes
(2024-10-23)Background: Turner syndrome (TS) affects 1/2500 live born girls and is caused by a complete or partial loss of an X chromosome. It is characterized by short stature, ovarian dysfunction, congenital heart disease and an ... -
Prognostic factors for lower limb revascularization outcomes
(2024-10-23)Aim: The aim of this thesis was to investigate the applicability of preoperative magnetic resonance angiography (MRA) examinations regarding assessment of infrapopliteal lesion severity; to assess the agreement, reproducibility ... -
ldentification of viruses, their viability and purification in drinking water
(2024-10-14)This thesis aimed to identify viruses commonly found in water sources and assess the efficiency of water barriers in viral reduction at drinking water treatment plants (DWTPs) over time. Cell culture assays and molecular ... -
Artificial intelligence in assessment of skin tumours in digital pathology
(2024-10-14)The rising incidence of skin cancers has led to an increased burden on dermatopathology laboratories. The advent of digitalization offers the opportunity to integrate artificial intelligence (AI) into digital pathology ... -
Targeting Glutathione metabolism in cancer - a new therapeutic approach
(2024-10-14)Antioxidants have long been considered as potential cancer-preventive agents, though most clinical trials have failed to demonstrate significant benefits from antioxidant supplements. Recent scientific findings, however, ... -
Laparoscopic lavage in Swedish routine care 2016-2018. The LapLav study
(2024-10-02)Aim: The aim of the thesis was to compare laparoscopic lavage with resection surgery for perforated diverticulitis. Method: All patients operated for perforated diverticulitis in Sweden between 2016-2018 were identified ... -
The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease
(2024-09-26)The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ... -
Frailty in Older Adults in China -Trajectories, Determinants, and Impacts on Healthcare Utilization and Mortality
(2024-09-26)Frailty, though not a disease in itself, often precedes the onset of illness and is frequently overlooked. Research has paid insufficient attention to frailty as a dynamic phenomenon, particularly its longitudinal changes. ... -
Determinants and risk factors for early risk stratification and optimal secondary pevention in ischemic heart disease
(2024-09-26)Background: Ischemic heart disease is the leading cause of death globally. To combat ischemic heart disease and its challenges we must improve secondary prevention for those already affected and prevent its onset in a ... -
Outcomes of chronic and vertically acquired occult hepatitis B
(2024-09-26)Background: Chronic hepatitis B virus (HBV) infection is one of the major chronic infections and still in 2017 the most common cause for liver cirrhosis and hepatocellular carcinoma (HCC, liver cancer) in the world. Occult ... -
Flap-based breast reconstruction: clinical studies on donor sites, patient satisfaction, and health economics
(2024-09-24)Background: Breast cancer is the most common cancer in women. Surgical treatment involves resection of a portion or the whole breast. There are multiple ways to reconstruct a breast, most commonly with implants or transfer ... -
Social and motor coordination: methods development and applications in ESSENCE
(2024-09-24)This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ... -
Survival of patients with glioblastoma - advancements in the past two decades
(2024-09-24)Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ...