Sahlgrenska Academy / Sahlgrenska akademin
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Tumor metastasis: mechanisms and prevention
(2024-11-07)Metastatic spread of tumor cells accounts for the majority of cancer-related deaths. We have developed cancer vaccines based on the immunostimulatory adjuvant cholera toxin A1 (CTA1), including vaccines that deliver tumor ... -
Translational aspects of Gastrointestinal stromal tumors
(2024-11-07)Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, driven by mutations in KIT and PDGFRA in the majority of cases. This thesis explores several translational ... -
Sudden cardiac arrest in relation to exercise
(2024-11-07)Background: In predisposed individuals with a known or unknown cardiovascular disease, the risk of a sudden cardiac arrest is increased during and immediately after exercise. The most common postmortem diagnosis of ... -
Identifying predictors of long-term effects of bariatric surgery - Analysis of samples and data from the Swedish Obese Subjects (SOS) study
(2024-11-06)Aim of the thesis: To identify predictors of long-term treatment outcomes after bariatric surgery. Material and methods: The Swedish Obese Subjects (SOS) study is a prospective controlled intervention study comparing ... -
Synovial fibroblast activation in rheumatoid arthritis - Role of disease-associated risk genes and effects of methotrexate
(2024-11-06)The overall aim of this thesis was to increase the knowledge of molecular mechanisms shaping the pathogenic phenotype of activated fibroblast-like synoviocytes (FLS), which are drivers of chronic inflammation and destruction ... -
Impact of JAK-inhibition on infections
(2024-11-06)With the growing arsenal of treatment options for immune modulation come great opportunities to help patients. However, tampering with immune cells and their various mediators is also associated with risk, including increased ... -
Functional MRI methods for imaging of patients with low back pain
(2024-11-06)Background. Non-specific low back pain (LBP) is the leading symptom causing disability over time. It is associated with degenerative alterations in intervertebral discs (IVDs). Magnetic resonance imaging (MRI) can only ... -
Novel signaling and treatment regimes in Anaplastic Lymphoma Kinase driven neuroblastoma models
(2024-11-04)In this thesis we aimed to unravel the importance of Alkal2 in neuroblastoma with the aid of preclinical murine models. We tested the hypothesis that Alkal2 can potentiate murine MYCN-driven neuroblastoma in absence ... -
Cancer genetic risk assessment - Studies on genetic testing, genetic counselling and risk management
(2024-10-31)The assessment for hereditary cancer is a consultative service in clinical genetics and cancer care that includes genetic testing and genetic counselling for patients and their relatives, defining elevated cancer risk, and ... -
Person-centered collaboration in the sick leave and rehabilitation process - in a primary care context
(2024-10-31)Aim: This thesis focuses on chronic illness and long-term health-related impairments in work ability, with the overarching aim of expanding knowledge about the sick leave and rehabilitation process (SRP) to support primary ... -
Evaluation of long-term outcomes after anterior cruciate ligament reconstruction. Operative methods, clinical and radiological findings, and their relationship to patient-reported acceptable knee function
(2024-10-29)The overarching theme of this thesis was to evaluate long-term clinical, subjective and radiological results after anterior cruciate ligament (ACL) reconstruction in regard to: different surgical methods, specifically ... -
Primary Aldosteronism; a growing challenge
(2024-10-29)Primary aldosteronism (PA), caused by excessive aldosterone production, is a frequently overlooked cause of hypertension. Cardiovascular complications are more common in patients with PA than patients with essential ... -
Cardiometabolic disease and cancer. Effects of body weight and diabetes
(2024-10-23)Background: The rise in overweight and obesity rates is associated with an increase in various forms of cardiovascular disease (CVD) and cancer. Moreover, an increasing proportion of young people with diabetes have type 2 ... -
Spiritual Care Unveiled - Religious Literacy in Palliative Care
(2024-10-23)Sweden is portrayed as being multicultural and multireligious and at the same time, significantly impacted by secularization and simultaneously highly influenced by secular values. This diversity necessitates that society ... -
Aortic Dissection in Turner Syndrome - Risk factors and Long-term Outcomes
(2024-10-23)Background: Turner syndrome (TS) affects 1/2500 live born girls and is caused by a complete or partial loss of an X chromosome. It is characterized by short stature, ovarian dysfunction, congenital heart disease and an ... -
Prognostic factors for lower limb revascularization outcomes
(2024-10-23)Aim: The aim of this thesis was to investigate the applicability of preoperative magnetic resonance angiography (MRA) examinations regarding assessment of infrapopliteal lesion severity; to assess the agreement, reproducibility ... -
ldentification of viruses, their viability and purification in drinking water
(2024-10-14)This thesis aimed to identify viruses commonly found in water sources and assess the efficiency of water barriers in viral reduction at drinking water treatment plants (DWTPs) over time. Cell culture assays and molecular ... -
Artificial intelligence in assessment of skin tumours in digital pathology
(2024-10-14)The rising incidence of skin cancers has led to an increased burden on dermatopathology laboratories. The advent of digitalization offers the opportunity to integrate artificial intelligence (AI) into digital pathology ... -
Targeting Glutathione metabolism in cancer - a new therapeutic approach
(2024-10-14)Antioxidants have long been considered as potential cancer-preventive agents, though most clinical trials have failed to demonstrate significant benefits from antioxidant supplements. Recent scientific findings, however, ... -
Laparoscopic lavage in Swedish routine care 2016-2018. The LapLav study
(2024-10-02)Aim: The aim of the thesis was to compare laparoscopic lavage with resection surgery for perforated diverticulitis. Method: All patients operated for perforated diverticulitis in Sweden between 2016-2018 were identified ...