• Ultrasensitive nucleic acids analysis using digital sequencing 

  Luna Santamaria, Manuel (2025-01-24)

  Liquid biopsies offer a minimally invasive and affordable procedure to obtain valuable clinical insights through biomarker analysis that can aid to manage the care of different diseases and health conditions. Analysis of ...

• Exploring the source of human cardiac regeneration 

  Sjölin, Linnéa (2025-01-21)

  The human heart is known to have limited regenerative capacity, and the source of new cardiomyocytes remains enigmatic. The existence of stem cells in the adult human heart has been a topic of debate. Recently, a potential ...

• Evaluating Virtual Reality and Artificial lntelligence as Emerging Digital Tools for Mental Health Care 

  Almira, Osmanovic Thunström (2025-01-16)

  This thesis evaluates the potential of Virtual Reality (VR) and Artificial Intelligence (AI), specifically Natural Language Processing (NLP) and Large Language Models (LLMs), as emerging tools for mental health care. VR ...

• Drug interactions in healthcare - Knowledge resources and clinical management 

  Tukukino, Carina (2025-01-14)

  Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ...

• Gravitostat: A Homeostatic Regulator of Body Weight 

  Zlatkovic, Jovana (2025-01-14)

  This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ...

• Advancements in the Neuropsychology of Alzheimer's Disease 

  Öhman, Fredrik (2025-01-08)

  Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ...

• The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system 

  Ademar, Karin (2025-01-08)

  Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ...

• Cardiopulmonary Phenotyping during Sleep - Innovative Signal Processing for Precision Medicine in Sleep Apnea 

  Strassberger, Christian (2024-12-18)

  Background: Obstructive sleep apnea (OSA) is one of the most common sleep disorders with a significant impact on public health. Various studies suggest that the contemporary methods of clinical sleep medicine are ...

• Translational studies to understand myocardial stunning in acute myocardial infarction 

  Espinosa Shekka, Aaron (2024-12-18)

  Myocardial stunning is a reversible contractile dysfunction that persists despite the resolution of myocardial ischemia. It is commonly associated with acute myocardial infarction. However, myocardial stunning also occurs ...

• Radiation-induced Dysphagia: Intervention and Assessment Tools for Head and Neck Cancer 

  Petersson, Kerstin (2024-12-16)

  Abstract The aim of the thesis was to evaluate the effect of two interventions to prevent or reduce complications of radiation-induced swallowing and mouth opening difficulties among HNC patients. An additional aim was ...

• Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease 

  Ge, Junyue (2024-12-11)

  The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ...

• Management of pregnancy of unknown location. Diagnostic protocols, clinical outcomes and psychosocial aspects 

  Fistouris, Johan (2024-12-10)

  Background: Ectopic pregnancy (EP) is the leading cause of pregnancy-related first trimester mortality. Many EP remain undiagnosed beyond an initial transvaginal ultrasound assessment. Noninvasive diagnosis of EP in women ...

• The importance of time in colorectal cancer treatment 

  Rydbeck, Daniel (2024-12-10)

  Aim To investigate aspects of time in colorectal cancer treatment and explore a method for predicting response to neoadjuvant treatment. Methods Paper I analyzed the association between age and time to diagnosis of ...

• Steroid-free immunosuppression in kidney transplantation 

  Ekberg, Jana (2024-12-05)

  Background: Steroids have been successfully used in kidney transplantation for six decades as part of different immunosuppressive protocols. To date, the most frequently used regimen is a combination of tacrolimus, ...

• Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease 

  Pradhan, Ajay (2024-12-04)

  Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ...

• Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up 

  Gómez Vecchio, Tomás Agustín (2024-12-04)

  The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ...

• Biomarker profiling in sepsis diagnostics 

  Irani Shemirani, Mahnaz (2024-11-28)

  Effective and timely antibiotic therapy for sepsis requires a thorough understanding of the types and molecular characteristics of bacterial strains. Therefore, we investigated diagnostic strategies to facilitate faster ...

• The roles of RNA m6A modification in disease mechanisms of high-risk neuroblastoma 

  Thombare, Ketan (2024-11-21)

  Epitranscriptomics involves covalent modifications of RNA bases, with N6-methyladenosine (m6A) being one of the most abundant and functionally characterized. This modification plays a key role in RNA metabolism, cellular ...

• Human B-cell development at the single-cell level 

  Sundell, Timothy (2024-11-21)

  B cells play an integral part of our immune system. In adults they develop in the bone marrow in a regulated process in which the specificity of their B-cell antigen receptor (BCR), a membrane bound antibody, is established. ...

• Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation 

  Ekhammar, Annika (2024-11-20)

  Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ...

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