Sahlgrenska Academy / Sahlgrenska akademin
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Drug interactions in healthcare - Knowledge resources and clinical management
(2025-01-14)Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ... -
Gravitostat: A Homeostatic Regulator of Body Weight
(2025-01-14)This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ... -
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ... -
The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system
(2025-01-08)Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ... -
Cardiopulmonary Phenotyping during Sleep - Innovative Signal Processing for Precision Medicine in Sleep Apnea
(2024-12-18)Background: Obstructive sleep apnea (OSA) is one of the most common sleep disorders with a significant impact on public health. Various studies suggest that the contemporary methods of clinical sleep medicine are ... -
Translational studies to understand myocardial stunning in acute myocardial infarction
(2024-12-18)Myocardial stunning is a reversible contractile dysfunction that persists despite the resolution of myocardial ischemia. It is commonly associated with acute myocardial infarction. However, myocardial stunning also occurs ... -
Radiation-induced Dysphagia: Intervention and Assessment Tools for Head and Neck Cancer
(2024-12-16)Abstract The aim of the thesis was to evaluate the effect of two interventions to prevent or reduce complications of radiation-induced swallowing and mouth opening difficulties among HNC patients. An additional aim was ... -
Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Management of pregnancy of unknown location. Diagnostic protocols, clinical outcomes and psychosocial aspects
(2024-12-10)Background: Ectopic pregnancy (EP) is the leading cause of pregnancy-related first trimester mortality. Many EP remain undiagnosed beyond an initial transvaginal ultrasound assessment. Noninvasive diagnosis of EP in women ... -
The importance of time in colorectal cancer treatment
(2024-12-10)Aim To investigate aspects of time in colorectal cancer treatment and explore a method for predicting response to neoadjuvant treatment. Methods Paper I analyzed the association between age and time to diagnosis of ... -
Steroid-free immunosuppression in kidney transplantation
(2024-12-05)Background: Steroids have been successfully used in kidney transplantation for six decades as part of different immunosuppressive protocols. To date, the most frequently used regimen is a combination of tacrolimus, ... -
Adult psychiatric outpatients; neuropsychiatric, neuropsychological and neurodevelopmental aspects
(2024-12-05)ABSTRACT Background: Neurodevelopmental disorders - including autism and attention- deficit/hyperactivity (ADHD) - are relatively common in the general population with a total prevalence rate of at least 10%. Most research ... -
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
(2024-12-04)Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ... -
Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up
(2024-12-04)The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ... -
Biomarker profiling in sepsis diagnostics
(2024-11-28)Effective and timely antibiotic therapy for sepsis requires a thorough understanding of the types and molecular characteristics of bacterial strains. Therefore, we investigated diagnostic strategies to facilitate faster ... -
The roles of RNA m6A modification in disease mechanisms of high-risk neuroblastoma
(2024-11-21)Epitranscriptomics involves covalent modifications of RNA bases, with N6-methyladenosine (m6A) being one of the most abundant and functionally characterized. This modification plays a key role in RNA metabolism, cellular ... -
Human B-cell development at the single-cell level
(2024-11-21)B cells play an integral part of our immune system. In adults they develop in the bone marrow in a regulated process in which the specificity of their B-cell antigen receptor (BCR), a membrane bound antibody, is established. ... -
Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation
(2024-11-20)Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ... -
Prerequisites and effects of an opioid-free anaesthesia pathway in patients undergoing bariatric surgery
(2024-11-20)Obesity is an escalating public health concern and bariatric surgery remains the only effective long-term treatment for substantial weight reduction. However, bariatric surgery typically involves opioid use during and ... -
Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome
(2024-11-19)Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ...
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