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Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)
Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ...
Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development
(2010-02-18)
Abstract
GENETICS OF PARKINSON’S DISEASE
- WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT
Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be ...
On the importance of inflammation for personality traits and psychiatric morbidity
(2010-12-10)
Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. neurodevelopmental ...
Influence of inflammation and of stage of lung development on the development of neonatal lung injury
(2010-11-26)
Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)
Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ...
Inflammation and Cell Profileration Following Perinatal Brain Injury
(2010-08-30)
Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ...