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Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
Transcriptional profiling of human embryonic stem cells and their functional derivatives
(2010-10-07)
Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. ...
On the importance of inflammation for personality traits and psychiatric morbidity
(2010-12-10)
Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. neurodevelopmental ...
Functional analysis of the -1087 single nucleotide polymorphism in the IL-10 promoter region.
(2010-11-15)
Interleukin (IL) 10 is recognized as a pro-inflammatory cytokine that promotes B cell proliferation. The objectives of the present series of studies were to analyze (i) differences in transcription factor binding to the ...
On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain
(2010-09-28)
The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused ...