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Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ...
IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice
It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ...
Urethral strictures in men: Studies on reconstructive surgery and pathophysiology
Urethral stricture is a common disease that is characterised by fibrotic tissue arising from inflammation after urethral injury. Urination is inhibited when there is total obstruction, and the suffering is immense. Following ...
Bone and fat tissue in children and adolescents: studies with focus on osteocalcin
The general AIM was to investigate the possible interplay between bone and fat tissue through clinical studies of children and adolescents. Osteocalcin (OC), a bone formation marker, has been proposed to act as a link ...
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ...