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Estrogen and 2-methoxyestradiol: regulation of arthritis, inflammation and reactive oxygen species
Rheumatoid arthritis (RA) is characterized by severe synovial inflammation, cartilage destruction, and immune-mediated bone loss. Estrogen ameliorates experimental RA, reducing both inflammation and bone loss. The inflamed ...
Regulation of metabolism and inflammation by two protein kinases - AMPK and STK25
Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder that has reached epidemic proportions globally, and is now considered to be one of the main threats to human health. The currently available treatment ...
DIAVIP - Diabetes Prevention in Primary Care - Implications for Physical Activity
Aim: The overall aim was to study the effect of physical activity in impaired glucose tolerance (IGT) and insulin resistance. We set out to: 1. Evaluate different screening instruments to identify individuals with IGT; ...
The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective ...