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Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule ...
Regulation of mucosal inflammation by fibroblasts
ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ...
Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance
Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is ...