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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

Mathew, Nimitha Rose; Jayanthan, Jayalal; Smirnov, Ilya; Robinson, Jonathan L; Axelsson, Hannes; Sowdamini Nakka, Sravya; Emmanouilidi, Aikaterini; Czarnewski, Paulo; Yewdell, William T; Schön, Karin; Lebrero-Fernandez, Cristina; Bernasconi, Valentina; Rodin, William; Harandi, Ali M; Lycke, Nils Y; Borcherding, Nicholas; Yewdell, Jonathan W; Greiff, Victor; Bemark, Mats; Angeletti, Davide (2022)

B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, ...

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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells