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The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury
(2022-01-13)
The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common ...
Biomarkers in mid-trimester amniotic fluid in relation to gestational duration and spontaneous preterm delivery
(2020-05-15)
Background: The biological mechanisms and physiological pathways of pregnancy maintenance and timing of delivery are complex and multifactorial. Pregnancy clocks, partly controlled by timing mechanisms linked to fetal ...
On the biological response to different biomaterials under normal and irradiated conditions
(2022-03-10)
There are several challenges when introducing an implant into a host. Concerning soft tissues, major complications are fibrosis and capsule contracture, whereas for bone, failure of osseointegration may occur. In addition ...
Short- and long-term outcomes after aneurysmal subarachnoid hemorrhage
(2023-09-15)
Aneurysmal subarachnoid hemorrhage (aSAH) is a sudden and devastating event with significant morbidity and mortality. The development of delayed cerebral ischemia (DCI) is a major contributor to the observed high morbidity. ...
Priming and activation of neutrophils from blood and tissue
(2023-03-17)
Inflammation is a powerful process, involved in many disease states, as well as in physiological situations. Neutrophils, the main characters of this thesis, are potent immune cells with the capacity to regulate inflammatory ...