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Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
(2007-03-26)
This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better ...
Myocardial creatine metabolism in experimental infarction and heart failure
(2007-10-04)
The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as
pathologic remodelling. An important part of this negative remodelling process is disturbances ...
Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans
(2007-04-28)
Effects of Oestrogen on Haemodynamic and Vascular Reactivity
A study in animal models and humans
Lisa Brandin
Institute of Medicine, Department of Emergency and Cardiovascular Medicine,
Sahlgrenska University Hospital/Östra, ...
Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)
This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ...
Boys with Asperger Syndrome grown up. A longitudinal follow-up study of 100 cases more than 5 years after original diagnosis
(2007-03-09)
Introduction and aims: In 1981, the diagnostic label of Asperger Syndrome (AS), was coined after the Austrian paediatrician Hans Asperger, by the English psychiatrist Lorna Wing, who reintroduced his 1944 work about “die ...
Studies on pathophysiological mechanisms in experimental models of acute renal failure
(2007-02-19)
Acute renal failure (ARF) affects 5-20 % of critically ill patients and is an independent risk factor for death in this patient population. Reactive oxygen species, thrombin and endothelin-1 (ET-1) are increased in ARF, ...
Dyspnea Experience and Quality of Life among persons with lung cancer in palliative care
(2007-01-12)
Background: Dyspnea, a subjective, multidimensional experience of breathing discomfort commonly occurring in patients with incurable lung cancer, influences all aspects of life in the suffering per¬sons. To optimally enhance ...
Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
(2007-09-10)
Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins ...
Sensory and secretory responses to intestinal distension; implications for the pathophysiology of the irritable bowel syndrome
(2007-06-18)
Irritable bowel syndrome (IBS) is a common gut disorder, characterized by abdominal pain and/or discomfort associated with disturbed bowel habits. The pathophysiology of IBS is complex and still largely unknown, although ...
Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell
(2007-08-31)
Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but ...