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Now showing items 11-20 of 149
Podocyte Melanocortin 1 Receptor Mediated Signaling
(2015-09-10)
Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by ...
Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
(2015-05-18)
ABSTRACT
Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene ...
Aspects on the management of patients with eosinophilic esophagitis
(2015-05-11)
Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the ...
Obstructive Sleep Apnea in Cardiovascular Disease - Mechanisms and Impact of Treatment
(2015-10-29)
ABSTRACT
Background: Scientific understanding of obstructive sleep apnea (OSA) has increased
exponentially during recent decades, suggesting a link between OSA and cardiovascular disease. Few randomized controlled trials ...
Genetic studies of autism and autistic-like traits
(2015-01-09)
Autism spectrum disorder (ASD) is characterized by impairment in social interaction,
language impairment and repetitive behavior with varying degrees of severity. ASD
represents the lower end on a continuously distributed ...
Potentially Malignant Disorders and Oral cancer -A study on Immunosurveillance
(2015-01-09)
ABSTRACT
The cancer immunosurveillance hypothesis postulates that the immune system can recognize cancer cell precursors and destroy those cells before a clinical manifestation occurs. During the last decades several ...
Mass spectrometric quantification of amyloid-beta in cerebrospinal fluid and plasma
(2015-10-07)
Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and accounts for 60-80% of all cases of dementia. Currently, the diagnosis of AD is based on cognitive tests and mental state exams, ...
Mediator and cell cycle regulation
(2015-11-04)
The multiprotein Mediator complex is an evolutionarily conserved coregulator of eukaryotic transcription. Mediator functions as a bridge between gene-specific transcription factors and the RNA polymerase II transcription ...
Re-evaluation of the hypothesis that LTP has two temporal phases and that the late phase is protein synthesis-dependent
(2015-02-19)
Long-term potentiation (LTP) is an activity-dependent increase in synaptic efficacy that is most studied in the hippocampus and that is considered a cellular substrate for learning and memory. Accepting the belief that the ...
On Complications to Cataract Surgery
(2015-04-08)
Cataract surgery, meaning exchange of the opaque lens in the eye with an artificial lens, is nowadays one of the most successful surgical procedures ever known. It is also the most frequent surgery performed in the Western ...