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Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)
Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ...
Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
(2007-09-10)
Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins ...
The Role of Gut Dysfunction and Nutritional Factors in Liver Cirrhosis
(2007-03-14)
Malnutrition is a common finding in patients with liver cirrhosis. Malnutrition has been
shown to be associated with increased morbidity and mortality. Its pathogenesis remains
unclear but both poor dietary intake and ...
The assembly of cytosolic lipid droplets and its effect on insulin sensitivity
(2007-12-21)
Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation ...