It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ...

Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These ...

During infections, circulating cytokines are largely produced by immune cells. In healthy obese individuals, large parts of these circulating cytokines are produced in adipose tissue, for instance by macrophages that have ...