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Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
Progression and treatment of experimental peri-implantitis
(2011-04-21)
Peri-implantitis is characterized by inflammatory lesions in peri-implant tissues and loss of supporting bone. The aims of the present series of studies were to analyze (i) spontaneous progression and (ii) the effect of ...
Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
(2014-05-09)
Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate ...
A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
(2016-05-13)
The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, ...
The percutaneous implant. The effects of design, host site and surgery on the tissue response
(2018-02-14)
This research project focuses on the multiple challenges associated with implants that breach the skin. The role of device design, host site, and surgical approach on tissue response and outcome are evaluated, experimentally ...
On the biological response to different biomaterials under normal and irradiated conditions
(2022-03-10)
There are several challenges when introducing an implant into a host. Concerning soft tissues, major complications are fibrosis and capsule contracture, whereas for bone, failure of osseointegration may occur. In addition ...