Now showing items 1-5 of 5
Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans
Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of ...
Cancer in organ transplant recipients
Tens of thousands of transplantations are performed around the world each year. Organ transplant recipients (OTR) are obliged to receive life-long medical treatment with immunosuppressive drugs to ensure graft function. ...
Childhood overweight and pubertal timing as predictors of adult cancer in men
Background and Aim Obesity is one of the leading causes of cancer globally. The importance of overweight in childhood for adult cancer risk, independent of overweight status in young adulthood is still unknown. Furthermore, ...
Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection
Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ...
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ...