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Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)
Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ...
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)
Abstract
Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ...
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox
(2019-03-13)
Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also ...
Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
(2019-09-04)
Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to ...