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A role of CD44 in atherosclerosis? Studies in mice and humans
Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the ...
The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible ...
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ...