Browsing Sahlgrenska Academy / Sahlgrenska akademin by Title
Now showing items 1913-1932 of 2863
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Paediatric sleep-disordered breathing - diagnostics and treatment
(2018-01-17)Sleep-disordered breathing (SDB) in children causes multiple health problems and diminished quality of life. It is usually caused by tonsil and adenoid hypertrophy and is traditionally treated with adenotonsillar surgery. ... -
Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging
(2019-12-19)Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along ... -
Pain in paediatric dentistry. Experiences, attitudes and knowledge from the perspective of the child, the adolescent and the dentist.
(2017-01-04)Aim. The overall aim of this thesis was to study the frequency and intensity of general and oral pain, and oral discomfort in Swedish children and adolescents (with or without a disability). A further objective was to ... -
Pain, gender norms and psychosocial resources. A critical appraisal of taken for granted ideas on men and women with pain
(2023-01-10)Background: Gender norms concerning pain are important to consider as they might lead to unequal treatment of men and women in health care. Aim: The overall aim of this thesis was to explore and describe gender norms ... -
Painting from Within - Developing and Evaluating a Manual-based Art therapy for Patients with Depression
(2017-09-13)Aim: The overall aim was to develop and evaluate a manual-based art-therapy programme for patients with depression, and hence, to clarify treatment effects and to describe participants’ experiences of the treatment. The ... -
Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ... -
Pancreatic Cancer. Experimental and Clinical Studies
(2013-09-20)Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms ... -
Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and ... -
Parathyroid Hormone Hyper- and Hypoparathyroidism Effect of Treatment and Long-term Follow-up Studies
(2024-01-10)Background: High or low parathyroid hormone (PTH) can be challenging in diagnosis and treatment. The prevalence and natural history of normocalcemic hyperparathyroidism (nHPT) are still not known. The knowledge gap regarding ... -
Parental time pressure and financial stress - Challenges for mental health of Nordic children and adolescents
(2014-12-02)Mental health problems are a significant public health concern affecting approximately 10-20% of children and adolescents worldwide. Parents’ conditions and experiences are important in determining children’s circumstances, ... -
Parkinson's disease and motor function - a validation of the PLM method
(2013-09-27)Aim: To validate the Posturo-Locomotor-Manual (PLM) test, an objective movement measurement system designed to measure movement disability in patients with Parkinsonism. Method: The reliability of the PLM test was determined ... -
Participation after stroke in a short- and long-term perspective
(2019-10-15)The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ... -
Participation in everyday life. Very old persons' experiences of daily occupation, occupation of interest and use of assistive devices.
(2007-05-24)The overall aim of the present thesis was to examine, extend and deepen the understanding of very old persons’ experience of participation in everyday life from an occupational perspective. The thesis consists of four ... -
Passive sampling of PAHs and some trace organic compounds in occupational and residential air: needs, evaluation and limits
(2010-05-11)Human exposure to elevated levels of polycyclic aromatic hydrocarbons (PAHs) and trace organic compounds (e.g. PCB, OCP, PBDE) can be related to negative health effects. This raises demands of exposure measurements to be ... -
Patent Foramen Ovale (PFO) and cryptogenic stroke or transient ischemic attack: a follow-up study
(2014-11-24)Aims: The overall aim of this thesis was to study the long-term clinical outcomes in terms of survival, complications, recurrent stroke or transient ischemic attack (TIA), and quality of life in a group of patients with ... -
Pathogenesis of Obesity and Effects of Treatment. Clinical and Molecular Studies on Body Fat, Energy Balance, and Weight Loss.
(2009-06-29)Obesity is common and related to many health problems including various forms of cancer. The condition arises from the imbalance between food intake and energy expenditure, and is strongly influenced by genetic factors. ... -
Pathogenic mechanisms affecting mitochondrial DNA replication and transcription
(2023-04-24)Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to ... -
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ... -
Pathophysiological regulation of white adipocyte exocytosis of different adiponectin molecular forms
(2019-03-06)In this thesis we have identified mechanisms involved in the exocytosis of different adiponectin molecular forms in health and in metabolic disease. We have also studied similarities and differences in depot-specific ... -
Pathophysiological role and clinical relevance of cytokines in hypertensive heart failure. A combined clinical and experimental study
(2007-12-06)Although mortality due to heart failure has decreased significantly in the last decade since the introduction of ACE-inhibitors and β-adrenergic receptor blockers in the management of heart failure, chronic heart failure ...