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Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease


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Title: Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease
Authors: Höglund, Kina 1976-
Issue Date: 2006
University: Göteborgs universitet/University of Gothenburg
Institution: The Sahlgrenska Academy
Sahlgrenska akademin, Institutionen för neurovetenskap och fysiologi
Date of Defence: 2006-06-15
Disputation: Psykiatriklinikens aula (V-aula), Sahlgrenska Universitetssjukhuset/Mölndal, kl. 13.00
Publication type: Doctoral thesis
Keywords: Alzheimer s disease
amyloid precursor protein
beta-amyloid
cholesterol
statins
CSF
Abstract: Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. This hypothesis is primarily based on disease causing mutations found in familial forms of AD. The sporadic form o... more
ISBN: 91-628-6781-4
URI: http://hdl.handle.net/2077/16877
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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