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Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs


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Title: Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs
Authors: Petersen, Anne 1962-
Issue Date: 2006
University: Göteborgs universitet/University of Gothenburg
Institution: Department of Medical Chemistry and Cell Biology
Avdelningen för medicinsk kemi och cellbiologi
Date of Defence: 2006-03-10
Disputation: Föreläsningssal Arvid Carlsson , Medicinaregatan 3, Göteborg, kl. 09.00
Publication type: Doctoral thesis
Keywords: oxidation
NSAIDs/ASA
dexamethasone
apoptosis
GSH
GSSG
proteasome
lens epithelial cells
mouse lens
cataract
Abstract: Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses.Human lens epithelial cells and intact mouse lenses were exposed to the non-steroid anti-inflammatory substances (NSAIDs) indomethacin, diclofenac, celecoxib and acetylsalicylic acid (ASA) as well as to the glucocorticoid ... more
ISBN: 91-628-6746-6
URI: http://hdl.handle.net/2077/16768
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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