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Comparative genome and proteome analysis of brain tissue from MK-801-treated rats


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Title: Comparative genome and proteome analysis of brain tissue from MK-801-treated rats
Authors: Paulson, Linda 1971-
Issue Date: 2005
University: Göteborgs universitet/University of Gothenburg
Institution: Institute of Clinical Neuroscience
Institutionen för klinisk neurovetenskap
Date of Defence: 2005-02-25
Disputation: Psykiatriklinikens aula, Sahlgrenska sjukhuset/Mölndal, kl. 13.00
Publication type: Doctoral thesis
Keywords: Schizophrenia
MK-801
rat
animal model
proteomics
genomics
Abstract: Symptoms of intoxication with non-competitive N-methyl-D-aspartate (NMDA)-receptor antagonists, closely mimic symptoms in patients with schizophrenia, and therefore [+]-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene-5,10-iminehydrogen-maleate (MK-801, dizocilpine) treated rodents are often used as a model for schizophrenia. To investigate if administration of the NMDA receptor antagonist MK-801 to rats would induce messenger ribonucleic acid (mRNA) or protein disturbances mimicking those o... more
ISBN: 91-628-6403-3
URI: http://hdl.handle.net/2077/16449
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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