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Proteolysis in lens epithelium. Basic Studies and Possible Implications for Cataract Formation


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Title: Proteolysis in lens epithelium. Basic Studies and Possible Implications for Cataract Formation
Authors: Andersson, Madeleine 1969-
Issue Date: 1999
University: Göteborgs universitet/University of Gothenburg
Institution: Department of Ophtalmology
Avdelningen för oftalmologi
Date of Defence: 1999-12-10
Publication type: Doctoral thesis
Keywords: Apoptosis
calpain
caspases
cataract
lactacystin
lens epithelium
oxidation
proteolysis
proteasome
staurosporin
Abstract: Aims: Proteolysis has been implied in cataract formation, but the proteases involved and their precise role has not been fully elucidated. The objectives of this thesis were to study the activity of three main non-lysosomal proteolytical systems; calpains, the proteasome and the caspases, in lens epithelium from clear and cataractous lenses and during potentially cataractogenic conditions.Methods: Human lens epithelium from cataractous lenses was obtained during cataract surgery (Sahlgrenska Uni... more
URI: http://hdl.handle.net/2077/11361
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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