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Regulation of vascular function by fluid mechanical forces. Development of a new vascular experimental platform for integrative physiological and molecular biological studies of living conduit vessels
(2000)
The vascular endothelium is a multifunctional interface between blood flow and target organs and is continuously exposed to fluid mechanical forces such as shear stress, compressive, and tensile forces. Both in vivo and ...
On angiotensin II type 2 receptors in the small intestine
(2003)
The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, ...
A qualitative and quantitative study of nitrotyrosine using mass spectrometry and immunochemistry
(2004)
Background: Reactive oxygen (ROS), and nitrogen (RNS) species are formed during normal metabolism and in higher concentration in pathological conditions. They may cause cellular damage when the antioxidant defence is unable ...
Aspects on luminal nitric oxide in relation to oesophageal acid exposure and mucosal integrity
(2004)
Nitric oxide (NO) exerts important neuromuscular control of the oesophagus, but little is known about the sources and effects of the NO present in the distal oesophageal lumen. These questions were presently addressed in ...
Vascular mechanisms in ovulation
(2003)
Ovulation is a unique biological process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of the oocyte. This process is initiated by the preovulatory surge of luteinizing ...
Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer
(2004)
Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger ...
Platelet protection during ECMO. In vitro studies
(2003)
Extracorporeal membrane oxygenation (ECMO) is a complex technique for providing life support in severe respiratory and cardiac failure. ECMO is however associated with several side effects where bleeding complications are ...
On the autonomic control of the lower urinary tract. Functional and morphological aspects in the normal and the inflamed urinary bladder
(2005)
The regulation of urinary bladder function involves interplay of signalling systems. Disturbances in any of the interactive systems may result in lower tract dysfunction, which is often apparent to the patient by urge to ...
Caspase-dependent and caspase-independent neuronal injury in the developing brain
(2004)
Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed ...