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On the initial inflammatory response to variations in biomaterial surface chemistry
(2004)
Aims. The aim of the present thesis was, firstly, to develop in vivo and ex vivo models for analysis of peri-implant exudate and implant adherent cells and, secondly, to characterize the early inflammatory response to ...
Tumor biological aspects of the mucin-like glycoprotein CD43
(2005)
Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a ...
The role of bacterial endotoxin in the immature brain
(2004)
Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, ...
Tolerance and injury mechanisms in the developing CNS
(2005)
The pathophysiological mechanisms underlying the development of hypoxic-ischemic (HI) brain injury has been the subject of extensive research yet a neuroprotective strategy to limit its progression is lacking.OBJECTIVES: ...
Assessment of experimental neurotrauma
(2000)
Model systems of closed head injury are designed to replicate aspects of traumatic brain injury, ischemia and epilepsy in man. The aim of this thesis was to (1) develop sensitive systems enabling analyses of the biochemical ...
Expression, regulation and fuction of small ubiquitin-related modifier-1. Interaction with nuclear proteins in vivo
(2005)
The small ubiquitin-related modifier-1 (SUMO-1) is a 101-amino acid, ~12 kDa protein that is 18% identical to ubiquitin. Posttranslational covalent tagging of proteins with SUMO-1 (SUMOylation) serves many functions. For ...
Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia
(2004)
The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to ...
Caspase-dependent and caspase-independent neuronal injury in the developing brain
(2004)
Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed ...