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Mechanisms behind anorexia in experimental cancer
(2004)
Cancer anorexia-cachexia syndrome (CACS) is observed in 80% of patients with advanced cancer and is one of the most frequent causes of death in cancer. CACS is multifactorial in origin and involves interactions of cytokines, ...
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)
The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ...
On Complications to Cataract Surgery
(2015-04-08)
Cataract surgery, meaning exchange of the opaque lens in the eye with an artificial lens, is nowadays one of the most successful surgical procedures ever known. It is also the most frequent surgery performed in the Western ...
Perinatal brain injury - markers and mediators. Non-protein-bound iron and pro-inflammatory cytokines in newborn infants and neonatal pigs
(2001)
Two groups of newborn infants have an increased risk for perinatal brain injury; preterm infants and term infants subjected to birth asphyxia. Experimental studies indicate that hypoxic-ischemic insults in the perinatal ...
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)
In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ...
The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1
(2005)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear ...
On the initial inflammatory response to variations in biomaterial surface chemistry
(2004)
Aims. The aim of the present thesis was, firstly, to develop in vivo and ex vivo models for analysis of peri-implant exudate and implant adherent cells and, secondly, to characterize the early inflammatory response to ...
Modulation of Inflammatory Response in Surgical Trauma
(2012-09-12)
Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. The thesis aims to describe the body's inflammatory ...
On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants
(2018-11-22)
Orthopaedic implants enable the restitution of locomotor function and improve the quality of life of many people. However, biomaterial-associated infection may occur due to the propensity of microorganisms to adhere and ...
Cancer-related fatigue. Experience and outcomes
(2004)
Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in cancer patients and it may interfere with everyday aspects of life. Despite the recent significant increase in the literature on CRF it is ...