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Tissue engineering for novel female infertillity treatments: studies on small and large animal models
(2021-02-25)
Introduction: As with any transplantation (Tx) procedure, uterus Tx is associated with risky donor surgery and adverse side-effects from immunosuppression. With the aim to bypass these risks, this thesis investigated uterus ...
Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I
(2001)
Connexins form gap junctions that are aqueous pores allowing low-molecular (<1000 daltons) compounds to pass from cell to cell. In astroglial cells, connexin43 (cx43) makes up gap junctions, which in turn mediate ...
Development and Evaluation of Web Applications for Investigating Candidate Genes in Rat Models of Complex Diseases
(2008-11-21)
Many human diseases, such as rheumatoid arthritis and type 2 diabetes mellitus, have a very complex development, depending on both environmental and multiple genetic factors. By crossing inbred rat strains susceptible to ...
On the Autonomic Control of Blood Flow and Secretion in Salivary Glands. Functional and morphological aspects on muscarinic receptor subtypes in different species.
(2008-02-25)
Parasympathetic nervous activity is the principal stimulus for evoking fluid responses within salivary glands. Concomitantly to the onset of this response, the blood flow increases. The responses, in particular the ...
Neuronal networks involved in low back pain; experimental studies
(2012-10-08)
Low back pain is a common cause of disability, with a lifetime prevalence of up to 80%. A lumbar disc herniation, involving a bulging disc and/or leakage of the intervertebral disc’s nucleus pulposus, may be a possible ...
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)
Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ...
Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms
(2006)
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine ...
Masticatory retraining effect on masseter muscle, facial morphology and alveolar bone structure in the adult rat
(2018-11-12)
The aim of this series of investigations was to study the effect of masticatory muscle
retraining in adult rats with an earlier reduced masticatory muscle function on the
craniofacial morphology, on the internal alveolar ...
GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function
(2009-08-24)
Abstract
Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments ...