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Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional
serine/threonine kinase and endoribonuclease that is the major mediator of
the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
The association ...
Identification and characterization of candidate genes for neuroblastoma development
(2006)
Aim: Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features ...
Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
(2014-04-25)
Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner
nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ...
Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection
(2022-01-19)
Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ...
Integrative genomic and survival analysis of breast tumors
(2012-11-14)
With the continued accumulation of genomic data at ever increasing resolution the challenge ahead lies in reading out meaningful clinical/biological information form the data that can contribute to a better understanding ...
Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
(2013-11-29)
Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter ...
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)
One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ...
Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C
(2016-03-29)
Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further ...
Återhämtning och upplevd livskvalitet efter övre gastrointestinal kirurgi - ett patientperspektiv
(2009-05-14)
Bakgrund: Tidigare forskning som rör cancersjukdomar i matstrupe, magsäck och bukspottkörtel har beskrivits utifrån olika perspektiv såsom symtombild behandlingsmöjligheter, operationsteknik och komplikationer och har i ...