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Immunological, vascular and metabolic actions of androgens
(2020-03-10)
Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, ...
A role of CD44 in atherosclerosis? Studies in mice and humans
(2009-01-12)
Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the ...
The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
(2009-11-13)
A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible ...
Adipose tissue-derived serum amyloid A and adipose tissue macrophages in metabolic disease
(2013-11-29)
Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ...
Cardiovascular and metabolic control in obese children and adolescents
(2008-05-23)
Childhood obesity is an emerging risk factor for disease and mortality worldwide. The cardiovascular consequences and prevention thereof need to be further investigated. Exercise and weight loss are well examined and ...
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)
The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ...
Atherosclerosis in middle-aged men. A prospective study with focus on factors related to the metabolic syndrome
(2005)
The metabolic syndrome (MetS) is a clustering of cardiovascular disease CVD) risk factors. Pro-spective studies have demonstrated that patients with MetS are about three times more likely to experience CVD events than those ...
Imaging of coronary artery function and morphology in living mice - applications in atherosclerosis research
(2007-05-04)
Atherosclerosis in the coronary arteries is the major reason for myocardial infarction and cardiovascular death. In the clinic, several imaging systems make it possible to study coronary artery function and morphology ...
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)
The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ...
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)
The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ...