Search
Now showing items 1-7 of 7
Immunological, vascular and metabolic actions of androgens
(2020-03-10)
Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, ...
Adipose tissue-derived serum amyloid A and adipose tissue macrophages in metabolic disease
(2013-11-29)
Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ...
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)
The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ...
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)
The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ...
Actions of androgens and estrogens in experimental models of cardiovascular disease
(2010-10-31)
Men are at higher risk of developing both atherosclerotic cardiovascular disease and abdominal aortic aneurysm (AAA). Actions of sex steroids are hypothesized to underlie these gender differences. Testosterone, the major ...
Biological relevance and prognostic significance of radial artery intima-media thickness
(2014-03-14)
Cardiovascular disease (CVD) is the major cause of death both in Sweden and globally. Atherosclerotic vascular changes are considered the major underlying pathology leading to clinical manifestations of CVD, e.g. myocardial ...
Chronic limb-threatening ischaemia - Prognosis after intervention
(2019-04-26)
Introduction: Lower-extremity arterial disease (LEAD) is a major health problem worldwide. Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of LEAD. Open or endovascular recanalization is recommended ...